List of Receptors

Receptor Organism Cell type Mechanism of raft association Methods used to detect raft association Functional implication
Adenosine A1 receptor

Rat1, Pig2, Syrian hamster3

Ventricular cardiomyocyte1, Kidney epithelial cell2, Smooth muscle cell line3

Bound caveolin-31 and caveolin-13

Detergent-free1,2 Electron microscopy3, Confocal microscopy3

Agonist stimulation leads to translocation out of 1or into caveolae and caveolae-dependent internalization 2,3
Adenosine A2A receptor

Dog4, Rat 5

CHO cells4, Neonatal spinal cord5

Interact with caveolin-14

Confocal microscopy4, Detergent-dependent5

Internalization via raft-dependent mechanism4 
Adenosine A2B receptor

Human 6

Intestinal epithelial cell line 6

n.a

Detergent-free 6

The receptor localization in caveolae was increased after apical or basolateral stimulation of receptor with adenosine 6
Angiotensin II type 1 receptor

Rat7 8, Human9

VSMC7, 10, 11, BHK and HEK cells8, COS-7 cells9

Bound caveolin-17

Detergent-free7,8, Detergent-dependent8, Electron microscopy9

Agonist stimulation leads to translocation to caveolae7 or non-caveolin lipid raft8 or has no effect on localization9, Caveolin-binding mutation reduces the plasma membrane expression, agonist-dependent internalization and phospholipase C production9, Microtubules are essential in translocating the AT1 receptor to caveolae10, Receptors movement into caveolae is necessary for ROS production, Rac1 activation, Sos-1 tyrosine phosphorylation, ROS-dependent Akt phosphorylation and VSMC hypertrophy11
Bradykinin B1 receptor

Rabbit 12

HEK-293 12, 13

Putative caveolin binding motif 13

Confocal microscopy 12; Immunoblotting 13

Agonist induced caveolae translocation to caveolae12; Receptor localization in CLR did not changed in response to agonist 13
Bradykinin B2 receptor

Hamster 14; Human 13

HEK 293 13; DDT1-MF-2 smooth muscle cell 14; Epithelial carcinoma cell line 15; Aortic endothelial cells 16

Putative caveolin binding motif 13

Detergent-free 14, 16; Detergent-dependent 14, Confocal microscopy 15, Immunoblotting 13

Agonist BK induced movement of receptor, Gαq and Gαi to caveolae 15, 14; BK treatment leads to translocation of receptor out of caveolae 16; OR had no effect on localization 13
Calcium-sensing receptor

Bovine 17; Human 18

Parathyroid cells 17; Saos-2 cells 18; Cardiomyocytes 19

Bound caveolin-117 AND caveolin-3 19

Detergent-free 17,19, 18; Detergent-dependent 18

Ischemic preconditioning increases ERK1/2 phosphorylation in caveolin-3-enriched fraction 19
Cannabinoid receptor

Human 20, 21

Breast cancer MDA-MB-231 cells20; HEK-293 22,21

n.a

Detergent-free based on Opti prep density gradient 20; Confocal microscopy 20

Agonist treamtnet decreases the receptor associated with lipid raft 20; Receptor partially internalized via caveolae 22
CC chemokine receptor type 5 (CCR5)

Human 23, 24, 25

Human breast carcinoma MCF-7 cells 26; HeLa cells24; GEM NKR T cells 23; CHO cells25

Palmitoylation of C-terminal domain 27

Detergent-dependent 23; Immunofluorescence microscopy 24

Functional receptor localizes to lipid raft upon agonist treatment 23; CCR5 internalized via caveolae-dependent way 25
CC chemokine receptor type 6 (CCR6)

Human 28

Jurkat cells 28

n.a

Detergent-dependent 28

MβCD treatment impaired receptor-induced chemotaxis 28