List of Receptors

Receptor Organism Cell type Mechanism of raft association Methods used to detect raft association Functional implication
Melatonin receptor

Human 1

MCF-7 breast cancer cells 1

n.a

Immunoflourescence and confocal microscopy 1

n.a
metabotrotic gutamate receptor type 1

-

BHK-1α cells 2; HEK-293 3; MDCK 3; Cerebellum 4

n.a

Detergent-dependent 2; Confocal microscopy 2, 3; Detergent-dependent 3; Tandem affinity purification 3; Pull down assay 3

Agonist increases signaling in caveolin-enriched membrane 2; And also induce internalization via lipid raft/caveolae 3, 4; Caveolin-1 stabilizes surface expression of receptor 3
Neurokinin-1 receptor

Human 5, 6

HAoSMC 5, 6, 7; HepG2 5

n.a

Detergent-dependent 5; Fluorescence resonance energy transfer (FRET) 7; Electron paramagnetic resonance (EPR) in combination with GHOST consolidation procedure 6

MβCD and filipin treatments decrease receptor signaling such as ERK activation and phosphorylation 5; Caveolin mutation and MβCD treatment reduced NK-1R/β-arr2 interaction 6
Non-mammalian gonadotropin releasing hormone receptor

Chicken 8

COS-7 8; HEK-2938

Presumably palmitoylation 8

Immunoprecipitation 8

Caveolae-dpendent internalization 8
Oxytocin receptor

Human 9, 10

HEK-293 9; MDCK 10

Bound caveolin-2 10

Detergent-free 9; Detergent-dependent 9, 10

Agonist-induced localization in lipid raft increases or inhibits cell proliferation 10, 11
P2Y12 receptor

Human 12, 13

Platelets 12; HEK-293 13

n.a

Detergent-dependent 13

MβCD treatment reduced P2Y12-meidated inhibition of cAMP production and platelet aggregation 12
P2Y2 receptor

Mouse 14

Neuroblastoma × glioma NG 108-15 cells 14

n.a

Detergent-dependent 14

MβCD treatment inhibited P2Y2-induced Phospholipase C activation,Ca2+ mobilization and UTP-mediated cell migration 14
Pituitary adenylate cyclase-activating peptide receptor type 1 (PAC1R)

Rat 15

PC12 cells 15

n.a

Detergent-dependent 15; Confocal microscopy 15

PACAP stimulation induced receptor translocation into lipid raft/caveolae leading to cAMP production and neurite outgrowth 15
Platelet-activating factor receptor (PAFR)

Human 16

CHO cells 16; HEK-293 16

Putative palmitoylation site 16

Detergent-free 16

MβCD treatment reduced PAF-induced IP production, ca2+ mobilization and ERK phosphorylation 16
Prostanoid IP receptor

Human 17

COS-7 cells 17

n.a

Detergent-free 17; Immunofluorecence microscopy 17

IPR/AC signaling compartmentalized in lipid raft 17