Neurokinin-1 receptor

MβCD and filipin treatments decrease receptor signaling such as ERK activation and phosphorylation 1; Caveolin mutation and MβCD treatment reduced NK-1R/β-arr2 interaction 2

• 1. a. b. [399] Monastyrskaya, K, Hostettler A, Buergi S, Draeger A.  2005.  The NK1 receptor localizes to the plasma membrane microdomains, and its activation is dependent on lipid raft integrity. J Biol Chem. 280:7135-46.
• 2. a. b. [383] Kubale, V, Abramovic Z, Pogacnik A, Heding A, Sentjurc M, Vrecl M.  2007.  Evidence for a role of caveolin-1 in neurokinin-1 receptor plasma-membrane localization, efficient signaling, and interaction with beta-arrestin 2. Cell Tissue Res. 330:231-45.

n.a

• 1. a. b. c. [399] Monastyrskaya, K, Hostettler A, Buergi S, Draeger A.  2005.  The NK1 receptor localizes to the plasma membrane microdomains, and its activation is dependent on lipid raft integrity. J Biol Chem. 280:7135-46.
• 2. a. b. c. [383] Kubale, V, Abramovic Z, Pogacnik A, Heding A, Sentjurc M, Vrecl M.  2007.  Evidence for a role of caveolin-1 in neurokinin-1 receptor plasma-membrane localization, efficient signaling, and interaction with beta-arrestin 2. Cell Tissue Res. 330:231-45.
• 3. [397] Meyer, BH, Segura JM, Martinez KL, Hovius R, George N, Johnsson K, Vogel H.  2006.  FRET imaging reveals that functional neurokinin-1 receptors are monomeric and reside in membrane microdomains of live cells. Proc Natl Acad Sci U S A. 103:2138-43.

HAoSMC 1, 2, 3; HepG2 1

• 1. a. b. c. d. e. [399] Monastyrskaya, K, Hostettler A, Buergi S, Draeger A.  2005.  The NK1 receptor localizes to the plasma membrane microdomains, and its activation is dependent on lipid raft integrity. J Biol Chem. 280:7135-46.
• 2. a. b. c. d. [383] Kubale, V, Abramovic Z, Pogacnik A, Heding A, Sentjurc M, Vrecl M.  2007.  Evidence for a role of caveolin-1 in neurokinin-1 receptor plasma-membrane localization, efficient signaling, and interaction with beta-arrestin 2. Cell Tissue Res. 330:231-45.
• 3. a. b. [397] Meyer, BH, Segura JM, Martinez KL, Hovius R, George N, Johnsson K, Vogel H.  2006.  FRET imaging reveals that functional neurokinin-1 receptors are monomeric and reside in membrane microdomains of live cells. Proc Natl Acad Sci U S A. 103:2138-43.

Endogenous 1; Transient transfection 1, 3; Stable expression 2

• 1. a. b. c. d. e. f. g. h. [399] Monastyrskaya, K, Hostettler A, Buergi S, Draeger A.  2005.  The NK1 receptor localizes to the plasma membrane microdomains, and its activation is dependent on lipid raft integrity. J Biol Chem. 280:7135-46.
• 2. a. b. c. d. e. f. [383] Kubale, V, Abramovic Z, Pogacnik A, Heding A, Sentjurc M, Vrecl M.  2007.  Evidence for a role of caveolin-1 in neurokinin-1 receptor plasma-membrane localization, efficient signaling, and interaction with beta-arrestin 2. Cell Tissue Res. 330:231-45.
• 3. a. b. c. d. [397] Meyer, BH, Segura JM, Martinez KL, Hovius R, George N, Johnsson K, Vogel H.  2006.  FRET imaging reveals that functional neurokinin-1 receptors are monomeric and reside in membrane microdomains of live cells. Proc Natl Acad Sci U S A. 103:2138-43.