List of Receptors
Receptor | Organism | Cell type | Mechanism of raft association | Methods used to detect raft association | Functional implication |
---|---|---|---|---|---|
Glucagon-like peptide 2 receptor (GLP-2) |
Human 1 |
DLD-1 and BHK cells 1 |
n.a |
MβCD treatment inhibited receptor internalization and desensitization but not adenyly cyclase acivity 1 |
|
Histamin H1 receptor |
Human 2 |
CHO-K1 cells 2 |
n.a |
Confocal microscopy 2 |
Filipin or nystatin prevented histamine-induced internalization of receptor 2 |
Leukotriene B receptor |
n.a |
Detergent-dependent 3; Fluorescence resonance energy transfer (FRET) 3; Detergent-free 4 |
Agonist treatment did not alter receptor localization 3; MβCD treatment abolished LTB4-induced ca2+ mobilization and ERK1/2 phosphorylation 3; After igG-RBC treamtment receptor moved to lipid raft 4 |
||
Lipoxin A4 receptor |
Human 5 |
HEK-293 5 |
n.a |
Detergent-dependent 5 |
MβCD treatment reduces LXA4-dependent Platelet-derived growth factor receptor β dephosphorylation 5; LXA4 binding to receptor promotes SHP-2 recruitment to lipid raft 5 |
Luteinizing hormone receptor |
Rat 6 |
CHO cells 6 |
n.a |
Detergent-dependent 6 |
After human chorionic gonadotropin binding, receptors move to lipid raft 6,7; MβCD treatment reduced signaling 6 |
Lysophosphatidic acid receptor |
Pig 8 |
n.a |
MβCD treatment reduces LPA-inducd ERK1/2 phosphorylation 8 |
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M2 muscarinic receptor |
Ventricular myocytes 10; Cardiac myocytes 11; COS-7 cells 11 |
n.a |
Receptor translocates in to caveolae upon agonist treatment 10, 11; Possibly internalization by raft –dependent mechanism which negatively controls NO signaling 11 |
||
M3 muscarinic receptor |
n.a |
Caveolae disruption by cyclodextrin and caveolin-1 inhibition impairs ca2+ regulation12, 13; M3 muscarinic receptor colocalized with KATP channel subunit Kir6.1 in caveolae 14. |
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Mammalian gonadotropin releasing hormone receptor (mGnRHR) |
Mouse 16 |
Gonadotrope-derived α-T3-1 cell, CHO 16 |
n.a |
Cyclodextrin treatment attenuates GnRHR activation of ERK and induction of c-fos gene expression16 |
|
Melanin-concentrating hormone receptor (MCHR) |
- |
CHO-K1 cells 17 |
Bound caveolin-1 17 |
Detergent-free 17 |
MβCD treatment impaired MCH-mediated ERK signaling 17; There was no significant change in receptor localization after MCH treatment 17 |