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Mammalian gonadotropin releasing hormone receptor (mGnRHR)

Organism	Mouse 1 1. [401] Navratil, AM, Bliss SP, Berghorn KA, Haughian JM, Farmerie TA, Graham JK, Clay CM, Roberson MS. 2003. Constitutive localization of the gonadotropin-releasing hormone (GnRH) receptor to low density membrane microdomains is necessary for GnRH signaling to ERK. J Biol Chem. 278:31593-602.
Functional implication	Cyclodextrin treatment attenuates GnRHR activation of ERK and induction of c-fos gene expression1 1. a. b. [401] Navratil, AM, Bliss SP, Berghorn KA, Haughian JM, Farmerie TA, Graham JK, Clay CM, Roberson MS. 2003. Constitutive localization of the gonadotropin-releasing hormone (GnRH) receptor to low density membrane microdomains is necessary for GnRH signaling to ERK. J Biol Chem. 278:31593-602.
Methods used to detect raft association	Detergent-free 1, Detergent-dependent 1 1. a. b. c. d. [401] Navratil, AM, Bliss SP, Berghorn KA, Haughian JM, Farmerie TA, Graham JK, Clay CM, Roberson MS. 2003. Constitutive localization of the gonadotropin-releasing hormone (GnRH) receptor to low density membrane microdomains is necessary for GnRH signaling to ERK. J Biol Chem. 278:31593-602.
Mechanism of raft association	n.a 1. a. b. c. d. [401] Navratil, AM, Bliss SP, Berghorn KA, Haughian JM, Farmerie TA, Graham JK, Clay CM, Roberson MS. 2003. Constitutive localization of the gonadotropin-releasing hormone (GnRH) receptor to low density membrane microdomains is necessary for GnRH signaling to ERK. J Biol Chem. 278:31593-602.
Caveolin-binding motif
Cell type	Gonadotrope-derived α-T3-1 cell, CHO 1 1. a. b. c. d. e. [401] Navratil, AM, Bliss SP, Berghorn KA, Haughian JM, Farmerie TA, Graham JK, Clay CM, Roberson MS. 2003. Constitutive localization of the gonadotropin-releasing hormone (GnRH) receptor to low density membrane microdomains is necessary for GnRH signaling to ERK. J Biol Chem. 278:31593-602.
Species	Mouse 1; Hamster 1 1. a. b. c. d. e. f. g. [401] Navratil, AM, Bliss SP, Berghorn KA, Haughian JM, Farmerie TA, Graham JK, Clay CM, Roberson MS. 2003. Constitutive localization of the gonadotropin-releasing hormone (GnRH) receptor to low density membrane microdomains is necessary for GnRH signaling to ERK. J Biol Chem. 278:31593-602.
Receptor expression	α-T3-1 cell: Endogenous 1; CHO: stable transfection 1 1. a. b. c. d. e. f. g. h. i. [401] Navratil, AM, Bliss SP, Berghorn KA, Haughian JM, Farmerie TA, Graham JK, Clay CM, Roberson MS. 2003. Constitutive localization of the gonadotropin-releasing hormone (GnRH) receptor to low density membrane microdomains is necessary for GnRH signaling to ERK. J Biol Chem. 278:31593-602.

Refrences

Mouse 1; Hamster 1

1. a. b. c. d. e. f. g. [401] Navratil, AM, Bliss SP, Berghorn KA, Haughian JM, Farmerie TA, Graham JK, Clay CM, Roberson MS. 2003. Constitutive localization of the gonadotropin-releasing hormone (GnRH) receptor to low density membrane microdomains is necessary for GnRH signaling to ERK. J Biol Chem. 278:31593-602.