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M2 muscarinic receptor

Organism	Rat 1, 2 1. [358] Feron, O, Smith TW, Michel T, Kelly RA. 1997. Dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. J Biol Chem. 272:17744-8. 2. [354] Dessy, C, Kelly RA, Balligand JL, Feron O. 2000. Dynamin mediates caveolar sequestration of muscarinic cholinergic receptors and alteration in NO signaling. EMBO J. 19:4272-80.
Functional implication	Receptor translocates in to caveolae upon agonist treatment 1, 2; Possibly internalization by raft –dependent mechanism which negatively controls NO signaling 2 1. a. b. [358] Feron, O, Smith TW, Michel T, Kelly RA. 1997. Dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. J Biol Chem. 272:17744-8. 2. a. b. c. [354] Dessy, C, Kelly RA, Balligand JL, Feron O. 2000. Dynamin mediates caveolar sequestration of muscarinic cholinergic receptors and alteration in NO signaling. EMBO J. 19:4272-80.
Methods used to detect raft association	Detergent-free 1,2; Immunoprecipitation 1 1. a. b. c. d. [358] Feron, O, Smith TW, Michel T, Kelly RA. 1997. Dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. J Biol Chem. 272:17744-8. 2. a. b. c. d. [354] Dessy, C, Kelly RA, Balligand JL, Feron O. 2000. Dynamin mediates caveolar sequestration of muscarinic cholinergic receptors and alteration in NO signaling. EMBO J. 19:4272-80.
Mechanism of raft association	n.a 1. a. b. c. d. [358] Feron, O, Smith TW, Michel T, Kelly RA. 1997. Dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. J Biol Chem. 272:17744-8. 2. a. b. c. d. [354] Dessy, C, Kelly RA, Balligand JL, Feron O. 2000. Dynamin mediates caveolar sequestration of muscarinic cholinergic receptors and alteration in NO signaling. EMBO J. 19:4272-80.
Caveolin-binding motif	n.a 1. a. b. c. d. [358] Feron, O, Smith TW, Michel T, Kelly RA. 1997. Dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. J Biol Chem. 272:17744-8. 2. a. b. c. d. [354] Dessy, C, Kelly RA, Balligand JL, Feron O. 2000. Dynamin mediates caveolar sequestration of muscarinic cholinergic receptors and alteration in NO signaling. EMBO J. 19:4272-80.
Cell type	Ventricular myocytes 1; Cardiac myocytes 2; COS-7 cells 2 1. a. b. c. d. e. [358] Feron, O, Smith TW, Michel T, Kelly RA. 1997. Dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. J Biol Chem. 272:17744-8. 2. a. b. c. d. e. f. [354] Dessy, C, Kelly RA, Balligand JL, Feron O. 2000. Dynamin mediates caveolar sequestration of muscarinic cholinergic receptors and alteration in NO signaling. EMBO J. 19:4272-80.
Species	Rat 1, 2; Monkey 2 1. a. b. c. d. e. f. [358] Feron, O, Smith TW, Michel T, Kelly RA. 1997. Dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. J Biol Chem. 272:17744-8. 2. a. b. c. d. e. f. g. h. [354] Dessy, C, Kelly RA, Balligand JL, Feron O. 2000. Dynamin mediates caveolar sequestration of muscarinic cholinergic receptors and alteration in NO signaling. EMBO J. 19:4272-80.
Receptor expression	Endogenous 1; Cardiac myocyte: endogenous 2; COS-7 cells: transient transfection2 1. a. b. c. d. e. f. g. [358] Feron, O, Smith TW, Michel T, Kelly RA. 1997. Dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. J Biol Chem. 272:17744-8. 2. a. b. c. d. e. f. g. h. i. j. [354] Dessy, C, Kelly RA, Balligand JL, Feron O. 2000. Dynamin mediates caveolar sequestration of muscarinic cholinergic receptors and alteration in NO signaling. EMBO J. 19:4272-80.

Refrences

Rat 1, 2; Monkey 2

1. a. b. c. d. e. f. [358] Feron, O, Smith TW, Michel T, Kelly RA. 1997. Dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. J Biol Chem. 272:17744-8.
2. a. b. c. d. e. f. g. h. [354] Dessy, C, Kelly RA, Balligand JL, Feron O. 2000. Dynamin mediates caveolar sequestration of muscarinic cholinergic receptors and alteration in NO signaling. EMBO J. 19:4272-80.