List of Receptors

Receptor Organism Cell type Mechanism of raft association Methods used to detect raft association Functional implication
Cholecystokinin receptor type 1 (CCK1)

Rat 1

CHO cells 1

Include palmitoylation site in C-terminal 1

Detergent-dependent 1; Confocal microscopy 1

Receptor partially internalized via caveolae 1
CXC chemokine receptor type 1 (CXCR1)

- 2

CX1-HEK cells 2

n.a

Fluorescence resonance energy transfer (FRET); Fluorescence recovery after photobleaching ( FRAP) 2

Ligand induced receptor movement to lipid raft 2
CXC chemokine receptor type 4 (CXCR4)

Human 3

HEK-293 3; PMBC 3; Sup T1 lymphoblastoid 4; PM1 T cells 5; Hematopoietic progenitor cell line KG1a 6

n.a

Confocal microscopy 3, 4, 5, 6; Electron microscopy 4; Detergent-dependent 5

Gp120 recruits receptor to lipid raft 4; MβCD treatment inhibits receptor internalization, SDF-1-induced migration and HIV infection 5, 6, 7
Dopamine D1 receptor

Human 8, 9; Rat 10

HEK-293 8; Proximal tubular cells 8,10; COS-7 cells 9

Interaction with caveolin 8; Bound caveolin-1 9

Detergent-free 8, 9, 10; Confocal microscopy 8; Bioluminescence Resonance Energy Transfer (BRET) 9

Agonist treatment causes the receptor shift to caveolar plasma membrane 8, 9, 10; Caveolin-2 antisense reduces cAMP accumulation 8; Caveolin-1 binding motif mutation and MβCD treatment abolish receptor internalization 9
Endothelin A receptor

Rat 11; Human 12

COS cells 11

Bound caveolin 11

Coimmunoprecipitation 11

Receptor localization in caveolae is important in signal transduction 11; Agonist induced receptor internalization 12
Endothelin B receptor

Rat 13; Plasmid 14

Primary astrocytes 13; HEK-293 14

Bound caveolin-1 14

Detergent-free 13; Detergent-dependent 14

Filipin treatment inhibits signaling 13; Receptor moves out of caveolae upon agonist treatment 14
Formyl peptide receptor

Human 15

U937 promonocytic leukemia cell line 15

n.a

Confocal microscopy 15

MβCD treatment  reduced receptor internalization and abolished ca2+ mobilization in response to ligand 15
Formyl peptide receptor like-1

Human 15

U87 astrocytoma cells 15; CHO cells 15

n.a

Detergent-dependent 15

MβCD treatment suppress WKYMVM-induced IKK, ERK and Akt phosphorylation 15
GABA-B receptor

Rat 16; Hamster 17

Cerebellum 16; CHO cells 17

n.a

Detergent-dependent 16, 17

Receptor localization in lipid raft may inhibit signaling 17
Glucagon-like peptide 1 receptor (GLP-1)

Mouse 18

MIN6 cells 18; HEK-293 18

Interaction with caveolin-1 18

Detergent-dependet 18

Receptor interaction with caveolin-1 is necessary for cellular trafficking; Receptor-induced ERK1/2 activity depends on lipid raft integrity; Agonist induced receptor internalization in association with cavelin-1 18