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Glucagon-like peptide 1 receptor (GLP-1)

Organism	Mouse 1 1. [473] Syme, CA, Zhang L, Bisello A. 2006. Caveolin-1 regulates cellular trafficking and function of the glucagon-like Peptide 1 receptor.. Molecular endocrinology (Baltimore, Md.). 20(12):3400-11.
Functional implication	Receptor interaction with caveolin-1 is necessary for cellular trafficking; Receptor-induced ERK1/2 activity depends on lipid raft integrity; Agonist induced receptor internalization in association with cavelin-1 1 1. a. b. [473] Syme, CA, Zhang L, Bisello A. 2006. Caveolin-1 regulates cellular trafficking and function of the glucagon-like Peptide 1 receptor.. Molecular endocrinology (Baltimore, Md.). 20(12):3400-11.
Methods used to detect raft association	Detergent-dependet 1 1. a. b. c. [473] Syme, CA, Zhang L, Bisello A. 2006. Caveolin-1 regulates cellular trafficking and function of the glucagon-like Peptide 1 receptor.. Molecular endocrinology (Baltimore, Md.). 20(12):3400-11.
Mechanism of raft association	Interaction with caveolin-1 1 1. a. b. c. d. [473] Syme, CA, Zhang L, Bisello A. 2006. Caveolin-1 regulates cellular trafficking and function of the glucagon-like Peptide 1 receptor.. Molecular endocrinology (Baltimore, Md.). 20(12):3400-11.
Caveolin-binding motif	Yes 1 1. a. b. c. d. e. [473] Syme, CA, Zhang L, Bisello A. 2006. Caveolin-1 regulates cellular trafficking and function of the glucagon-like Peptide 1 receptor.. Molecular endocrinology (Baltimore, Md.). 20(12):3400-11.
Cell type	MIN6 cells 1; HEK-293 1 1. a. b. c. d. e. f. g. [473] Syme, CA, Zhang L, Bisello A. 2006. Caveolin-1 regulates cellular trafficking and function of the glucagon-like Peptide 1 receptor.. Molecular endocrinology (Baltimore, Md.). 20(12):3400-11.
Species	Human 1; Mouse 1 1. a. b. c. d. e. f. g. h. i. [473] Syme, CA, Zhang L, Bisello A. 2006. Caveolin-1 regulates cellular trafficking and function of the glucagon-like Peptide 1 receptor.. Molecular endocrinology (Baltimore, Md.). 20(12):3400-11.
Receptor expression	Endogenous 1; Stable transfection 1; Transient transfection 1 1. a. b. c. d. e. f. g. h. i. j. k. l. [473] Syme, CA, Zhang L, Bisello A. 2006. Caveolin-1 regulates cellular trafficking and function of the glucagon-like Peptide 1 receptor.. Molecular endocrinology (Baltimore, Md.). 20(12):3400-11.

Refrences

Human 1; Mouse 1

1. a. b. c. d. e. f. g. h. i. [473] Syme, CA, Zhang L, Bisello A. 2006. Caveolin-1 regulates cellular trafficking and function of the glucagon-like Peptide 1 receptor.. Molecular endocrinology (Baltimore, Md.). 20(12):3400-11.