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CXC chemokine receptor type 1 (CXCR1)

Organism	- 1 1. [374] Jiao, X, Zhang N, Xu X, Oppenheim JJ, Jin T. 2005. Ligand-induced partitioning of human CXCR1 chemokine receptors with lipid raft microenvironments facilitates G-protein-dependent signaling. Mol Cell Biol. 25:5752-62.
Functional implication	Ligand induced receptor movement to lipid raft 1 1. a. b. [374] Jiao, X, Zhang N, Xu X, Oppenheim JJ, Jin T. 2005. Ligand-induced partitioning of human CXCR1 chemokine receptors with lipid raft microenvironments facilitates G-protein-dependent signaling. Mol Cell Biol. 25:5752-62.
Methods used to detect raft association	Fluorescence resonance energy transfer (FRET); Fluorescence recovery after photobleaching ( FRAP) 1 1. a. b. c. [374] Jiao, X, Zhang N, Xu X, Oppenheim JJ, Jin T. 2005. Ligand-induced partitioning of human CXCR1 chemokine receptors with lipid raft microenvironments facilitates G-protein-dependent signaling. Mol Cell Biol. 25:5752-62.
Mechanism of raft association	n.a 1. a. b. c. [374] Jiao, X, Zhang N, Xu X, Oppenheim JJ, Jin T. 2005. Ligand-induced partitioning of human CXCR1 chemokine receptors with lipid raft microenvironments facilitates G-protein-dependent signaling. Mol Cell Biol. 25:5752-62.
Caveolin-binding motif
Cell type	CX1-HEK cells 1 1. a. b. c. d. [374] Jiao, X, Zhang N, Xu X, Oppenheim JJ, Jin T. 2005. Ligand-induced partitioning of human CXCR1 chemokine receptors with lipid raft microenvironments facilitates G-protein-dependent signaling. Mol Cell Biol. 25:5752-62.
Species	Human 1 1. a. b. c. d. e. [374] Jiao, X, Zhang N, Xu X, Oppenheim JJ, Jin T. 2005. Ligand-induced partitioning of human CXCR1 chemokine receptors with lipid raft microenvironments facilitates G-protein-dependent signaling. Mol Cell Biol. 25:5752-62.
Receptor expression	Stable transfection 1 1. a. b. c. d. e. f. [374] Jiao, X, Zhang N, Xu X, Oppenheim JJ, Jin T. 2005. Ligand-induced partitioning of human CXCR1 chemokine receptors with lipid raft microenvironments facilitates G-protein-dependent signaling. Mol Cell Biol. 25:5752-62.

Refrences

Human 1

1. a. b. c. d. e. [374] Jiao, X, Zhang N, Xu X, Oppenheim JJ, Jin T. 2005. Ligand-induced partitioning of human CXCR1 chemokine receptors with lipid raft microenvironments facilitates G-protein-dependent signaling. Mol Cell Biol. 25:5752-62.