Leukotriene B receptor

Organism	Human 1; Rat 2 1. [427] Sitrin, RG, Emery SL, Sassanella TM, Blackwood RA, Petty HR. 2006. Selective localization of recognition complexes for leukotriene B4 and formyl-Met-Leu-Phe within lipid raft microdomains of human polymorphonuclear neutrophils. J Immunol. 177:8177-84. 2. [426] Serezani, CH, Aronoff DM, Sitrin RG, Peters-Golden M. 2009. FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. Blood. 114:3316-24.
Functional implication	Agonist treatment did not alter receptor localization 1; MβCD treatment abolished LTB4-induced ca2+ mobilization and ERK1/2 phosphorylation 1; After igG-RBC treamtment receptor moved to lipid raft 2 1. a. b. c. [427] Sitrin, RG, Emery SL, Sassanella TM, Blackwood RA, Petty HR. 2006. Selective localization of recognition complexes for leukotriene B4 and formyl-Met-Leu-Phe within lipid raft microdomains of human polymorphonuclear neutrophils. J Immunol. 177:8177-84. 2. a. b. [426] Serezani, CH, Aronoff DM, Sitrin RG, Peters-Golden M. 2009. FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. Blood. 114:3316-24.
Methods used to detect raft association	Detergent-dependent 1; Fluorescence resonance energy transfer (FRET) 1; Detergent-free 2 1. a. b. c. d. e. [427] Sitrin, RG, Emery SL, Sassanella TM, Blackwood RA, Petty HR. 2006. Selective localization of recognition complexes for leukotriene B4 and formyl-Met-Leu-Phe within lipid raft microdomains of human polymorphonuclear neutrophils. J Immunol. 177:8177-84. 2. a. b. c. [426] Serezani, CH, Aronoff DM, Sitrin RG, Peters-Golden M. 2009. FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. Blood. 114:3316-24.
Mechanism of raft association	n.a 1. a. b. c. d. e. [427] Sitrin, RG, Emery SL, Sassanella TM, Blackwood RA, Petty HR. 2006. Selective localization of recognition complexes for leukotriene B4 and formyl-Met-Leu-Phe within lipid raft microdomains of human polymorphonuclear neutrophils. J Immunol. 177:8177-84. 2. a. b. c. [426] Serezani, CH, Aronoff DM, Sitrin RG, Peters-Golden M. 2009. FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. Blood. 114:3316-24.
Caveolin-binding motif
Cell type	Neutrophil 1; Alveolar macrophage 2 1. a. b. c. d. e. f. [427] Sitrin, RG, Emery SL, Sassanella TM, Blackwood RA, Petty HR. 2006. Selective localization of recognition complexes for leukotriene B4 and formyl-Met-Leu-Phe within lipid raft microdomains of human polymorphonuclear neutrophils. J Immunol. 177:8177-84. 2. a. b. c. d. [426] Serezani, CH, Aronoff DM, Sitrin RG, Peters-Golden M. 2009. FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. Blood. 114:3316-24.
Species	Human 1; Rat 2 1. a. b. c. d. e. f. g. [427] Sitrin, RG, Emery SL, Sassanella TM, Blackwood RA, Petty HR. 2006. Selective localization of recognition complexes for leukotriene B4 and formyl-Met-Leu-Phe within lipid raft microdomains of human polymorphonuclear neutrophils. J Immunol. 177:8177-84. 2. a. b. c. d. e. [426] Serezani, CH, Aronoff DM, Sitrin RG, Peters-Golden M. 2009. FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. Blood. 114:3316-24.
Receptor expression	Endogenous 1, 2 1. a. b. c. d. e. f. g. h. [427] Sitrin, RG, Emery SL, Sassanella TM, Blackwood RA, Petty HR. 2006. Selective localization of recognition complexes for leukotriene B4 and formyl-Met-Leu-Phe within lipid raft microdomains of human polymorphonuclear neutrophils. J Immunol. 177:8177-84. 2. a. b. c. d. e. f. [426] Serezani, CH, Aronoff DM, Sitrin RG, Peters-Golden M. 2009. FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. Blood. 114:3316-24.

Refrences

Human 1; Rat 2

1. a. b. c. d. e. f. g. [427] Sitrin, RG, Emery SL, Sassanella TM, Blackwood RA, Petty HR. 2006. Selective localization of recognition complexes for leukotriene B4 and formyl-Met-Leu-Phe within lipid raft microdomains of human polymorphonuclear neutrophils. J Immunol. 177:8177-84.
2. a. b. c. d. e. [426] Serezani, CH, Aronoff DM, Sitrin RG, Peters-Golden M. 2009. FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. Blood. 114:3316-24.

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Leukotriene B receptor