P2Y12 receptor

Organism	Human 1, 2 1. [412] Quinton, TM, Kim S, Jin J, Kunapuli SP. 2005. Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation. J Thromb Haemost. 3:1036-41. 2. [423] Savi, P, Zachayus JL, Delesque-Touchard N, Labouret C, Herve C, Uzabiaga MF, Pereillo JM, Culouscou JM, Bono F, Ferrara P et al.. 2006. The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts. Proc Natl Acad Sci U S A. 103:11069-74.
Functional implication	MβCD treatment reduced P2Y12-meidated inhibition of cAMP production and platelet aggregation 1 1. a. b. [412] Quinton, TM, Kim S, Jin J, Kunapuli SP. 2005. Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation. J Thromb Haemost. 3:1036-41. 2. [423] Savi, P, Zachayus JL, Delesque-Touchard N, Labouret C, Herve C, Uzabiaga MF, Pereillo JM, Culouscou JM, Bono F, Ferrara P et al.. 2006. The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts. Proc Natl Acad Sci U S A. 103:11069-74.
Methods used to detect raft association	Detergent-dependent 2 1. a. b. [412] Quinton, TM, Kim S, Jin J, Kunapuli SP. 2005. Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation. J Thromb Haemost. 3:1036-41. 2. a. b. [423] Savi, P, Zachayus JL, Delesque-Touchard N, Labouret C, Herve C, Uzabiaga MF, Pereillo JM, Culouscou JM, Bono F, Ferrara P et al.. 2006. The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts. Proc Natl Acad Sci U S A. 103:11069-74.
Mechanism of raft association	n.a 1. a. b. [412] Quinton, TM, Kim S, Jin J, Kunapuli SP. 2005. Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation. J Thromb Haemost. 3:1036-41. 2. a. b. [423] Savi, P, Zachayus JL, Delesque-Touchard N, Labouret C, Herve C, Uzabiaga MF, Pereillo JM, Culouscou JM, Bono F, Ferrara P et al.. 2006. The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts. Proc Natl Acad Sci U S A. 103:11069-74.
Caveolin-binding motif
Cell type	Platelets 1; HEK-293 2 1. a. b. c. [412] Quinton, TM, Kim S, Jin J, Kunapuli SP. 2005. Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation. J Thromb Haemost. 3:1036-41. 2. a. b. c. [423] Savi, P, Zachayus JL, Delesque-Touchard N, Labouret C, Herve C, Uzabiaga MF, Pereillo JM, Culouscou JM, Bono F, Ferrara P et al.. 2006. The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts. Proc Natl Acad Sci U S A. 103:11069-74.
Species	Human 1, 2 1. a. b. c. d. [412] Quinton, TM, Kim S, Jin J, Kunapuli SP. 2005. Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation. J Thromb Haemost. 3:1036-41. 2. a. b. c. d. [423] Savi, P, Zachayus JL, Delesque-Touchard N, Labouret C, Herve C, Uzabiaga MF, Pereillo JM, Culouscou JM, Bono F, Ferrara P et al.. 2006. The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts. Proc Natl Acad Sci U S A. 103:11069-74.
Receptor expression	Endogenous 1; Transient expression 2 1. a. b. c. d. e. [412] Quinton, TM, Kim S, Jin J, Kunapuli SP. 2005. Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation. J Thromb Haemost. 3:1036-41. 2. a. b. c. d. e. [423] Savi, P, Zachayus JL, Delesque-Touchard N, Labouret C, Herve C, Uzabiaga MF, Pereillo JM, Culouscou JM, Bono F, Ferrara P et al.. 2006. The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts. Proc Natl Acad Sci U S A. 103:11069-74.

Refrences

Human 1, 2

1. a. b. c. d. [412] Quinton, TM, Kim S, Jin J, Kunapuli SP. 2005. Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation. J Thromb Haemost. 3:1036-41.
2. a. b. c. d. [423] Savi, P, Zachayus JL, Delesque-Touchard N, Labouret C, Herve C, Uzabiaga MF, Pereillo JM, Culouscou JM, Bono F, Ferrara P et al.. 2006. The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts. Proc Natl Acad Sci U S A. 103:11069-74.

Search whole site

P2Y12 receptor