metabotrotic gutamate receptor type 1

Organism	-
Functional implication	Agonist increases signaling in caveolin-enriched membrane 1; And also induce internalization via lipid raft/caveolae 2, 3; Caveolin-1 stabilizes surface expression of receptor 2 1. [348] Burgueno, J, Enrich C, Canela EI, Mallol J, Lluis C, Franco R, Ciruela F. 2003. Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions. J Neurochem. 86:785-91. 2. a. b. [359] Francesconi, A, Kumari R, Zukin RS. 2009. Regulation of group I metabotropic glutamate receptor trafficking and signaling by the caveolar/lipid raft pathway. J Neurosci. 29:3590-602. 3. [370] Hong, YH, Kim JY, Lee JH, Chae HG, Jang SS, Jeon JH, Kim CH, Kim J, Kim SJ. 2009. Agonist-induced internalization of mGluR1alpha is mediated by caveolin. J Neurochem. 111:61-71.
Methods used to detect raft association	Detergent-dependent 1; Confocal microscopy 1, 2; Detergent-dependent 2; Tandem affinity purification 2; Pull down assay 2 1. a. b. c. [348] Burgueno, J, Enrich C, Canela EI, Mallol J, Lluis C, Franco R, Ciruela F. 2003. Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions. J Neurochem. 86:785-91. 2. a. b. c. d. e. f. [359] Francesconi, A, Kumari R, Zukin RS. 2009. Regulation of group I metabotropic glutamate receptor trafficking and signaling by the caveolar/lipid raft pathway. J Neurosci. 29:3590-602. 3. [370] Hong, YH, Kim JY, Lee JH, Chae HG, Jang SS, Jeon JH, Kim CH, Kim J, Kim SJ. 2009. Agonist-induced internalization of mGluR1alpha is mediated by caveolin. J Neurochem. 111:61-71.
Mechanism of raft association	n.a 1. a. b. c. [348] Burgueno, J, Enrich C, Canela EI, Mallol J, Lluis C, Franco R, Ciruela F. 2003. Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions. J Neurochem. 86:785-91. 2. a. b. c. d. e. f. [359] Francesconi, A, Kumari R, Zukin RS. 2009. Regulation of group I metabotropic glutamate receptor trafficking and signaling by the caveolar/lipid raft pathway. J Neurosci. 29:3590-602. 3. [370] Hong, YH, Kim JY, Lee JH, Chae HG, Jang SS, Jeon JH, Kim CH, Kim J, Kim SJ. 2009. Agonist-induced internalization of mGluR1alpha is mediated by caveolin. J Neurochem. 111:61-71.
Caveolin-binding motif	Yes 2, 3 1. a. b. c. [348] Burgueno, J, Enrich C, Canela EI, Mallol J, Lluis C, Franco R, Ciruela F. 2003. Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions. J Neurochem. 86:785-91. 2. a. b. c. d. e. f. g. [359] Francesconi, A, Kumari R, Zukin RS. 2009. Regulation of group I metabotropic glutamate receptor trafficking and signaling by the caveolar/lipid raft pathway. J Neurosci. 29:3590-602. 3. a. b. [370] Hong, YH, Kim JY, Lee JH, Chae HG, Jang SS, Jeon JH, Kim CH, Kim J, Kim SJ. 2009. Agonist-induced internalization of mGluR1alpha is mediated by caveolin. J Neurochem. 111:61-71.
Cell type	BHK-1α cells 1; HEK-293 2; MDCK 2; Cerebellum 3 1. a. b. c. d. [348] Burgueno, J, Enrich C, Canela EI, Mallol J, Lluis C, Franco R, Ciruela F. 2003. Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions. J Neurochem. 86:785-91. 2. a. b. c. d. e. f. g. h. i. [359] Francesconi, A, Kumari R, Zukin RS. 2009. Regulation of group I metabotropic glutamate receptor trafficking and signaling by the caveolar/lipid raft pathway. J Neurosci. 29:3590-602. 3. a. b. c. [370] Hong, YH, Kim JY, Lee JH, Chae HG, Jang SS, Jeon JH, Kim CH, Kim J, Kim SJ. 2009. Agonist-induced internalization of mGluR1alpha is mediated by caveolin. J Neurochem. 111:61-71.
Species	Hamster 1; Human 2; Canine 2; Mouse 2; Rat 3, 2 1. a. b. c. d. e. [348] Burgueno, J, Enrich C, Canela EI, Mallol J, Lluis C, Franco R, Ciruela F. 2003. Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions. J Neurochem. 86:785-91. 2. a. b. c. d. e. f. g. h. i. j. k. l. m. [359] Francesconi, A, Kumari R, Zukin RS. 2009. Regulation of group I metabotropic glutamate receptor trafficking and signaling by the caveolar/lipid raft pathway. J Neurosci. 29:3590-602. 3. a. b. c. d. [370] Hong, YH, Kim JY, Lee JH, Chae HG, Jang SS, Jeon JH, Kim CH, Kim J, Kim SJ. 2009. Agonist-induced internalization of mGluR1alpha is mediated by caveolin. J Neurochem. 111:61-71.
Receptor expression	Permanently expressed 1; HEK-293: transient transfection 2; MDCK: transient transfection 2; neurons: endognous 2 1. a. b. c. d. e. f. [348] Burgueno, J, Enrich C, Canela EI, Mallol J, Lluis C, Franco R, Ciruela F. 2003. Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions. J Neurochem. 86:785-91. 2. a. b. c. d. e. f. g. h. i. j. k. l. m. n. o. p. [359] Francesconi, A, Kumari R, Zukin RS. 2009. Regulation of group I metabotropic glutamate receptor trafficking and signaling by the caveolar/lipid raft pathway. J Neurosci. 29:3590-602. 3. a. b. c. d. [370] Hong, YH, Kim JY, Lee JH, Chae HG, Jang SS, Jeon JH, Kim CH, Kim J, Kim SJ. 2009. Agonist-induced internalization of mGluR1alpha is mediated by caveolin. J Neurochem. 111:61-71.

Refrences

Hamster 1; Human 2; Canine 2; Mouse 2; Rat 3, 2

1. a. b. c. d. e. [348] Burgueno, J, Enrich C, Canela EI, Mallol J, Lluis C, Franco R, Ciruela F. 2003. Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions. J Neurochem. 86:785-91.
2. a. b. c. d. e. f. g. h. i. j. k. l. m. [359] Francesconi, A, Kumari R, Zukin RS. 2009. Regulation of group I metabotropic glutamate receptor trafficking and signaling by the caveolar/lipid raft pathway. J Neurosci. 29:3590-602.
3. a. b. c. d. [370] Hong, YH, Kim JY, Lee JH, Chae HG, Jang SS, Jeon JH, Kim CH, Kim J, Kim SJ. 2009. Agonist-induced internalization of mGluR1alpha is mediated by caveolin. J Neurochem. 111:61-71.

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metabotrotic gutamate receptor type 1