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Bradykinin B1 receptor

Organism	Rabbit 1 1. [420] Sabourin, T, Bastien L, Bachvarov DR, Marceau F. 2002. Agonist-induced translocation of the kinin B(1) receptor to caveolae-related rafts. Mol Pharmacol. 61:546-53.
Functional implication	Agonist induced caveolae translocation to caveolae1; Receptor localization in CLR did not changed in response to agonist 2 1. a. b. [420] Sabourin, T, Bastien L, Bachvarov DR, Marceau F. 2002. Agonist-induced translocation of the kinin B(1) receptor to caveolae-related rafts. Mol Pharmacol. 61:546-53. 2. [385] Lamb, ME, Zhang C, Shea T, Kyle DJ, Leeb-Lundberg LM. 2002. Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells. Biochemistry. 41:14340-7.
Methods used to detect raft association	Confocal microscopy 1; Immunoblotting 2 1. a. b. c. [420] Sabourin, T, Bastien L, Bachvarov DR, Marceau F. 2002. Agonist-induced translocation of the kinin B(1) receptor to caveolae-related rafts. Mol Pharmacol. 61:546-53. 2. a. b. [385] Lamb, ME, Zhang C, Shea T, Kyle DJ, Leeb-Lundberg LM. 2002. Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells. Biochemistry. 41:14340-7.
Mechanism of raft association	Putative caveolin binding motif 2 1. a. b. c. [420] Sabourin, T, Bastien L, Bachvarov DR, Marceau F. 2002. Agonist-induced translocation of the kinin B(1) receptor to caveolae-related rafts. Mol Pharmacol. 61:546-53. 2. a. b. c. [385] Lamb, ME, Zhang C, Shea T, Kyle DJ, Leeb-Lundberg LM. 2002. Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells. Biochemistry. 41:14340-7.
Caveolin-binding motif	Yes 2 1. a. b. c. [420] Sabourin, T, Bastien L, Bachvarov DR, Marceau F. 2002. Agonist-induced translocation of the kinin B(1) receptor to caveolae-related rafts. Mol Pharmacol. 61:546-53. 2. a. b. c. d. [385] Lamb, ME, Zhang C, Shea T, Kyle DJ, Leeb-Lundberg LM. 2002. Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells. Biochemistry. 41:14340-7.
Cell type	HEK-293 1, 2 1. a. b. c. d. [420] Sabourin, T, Bastien L, Bachvarov DR, Marceau F. 2002. Agonist-induced translocation of the kinin B(1) receptor to caveolae-related rafts. Mol Pharmacol. 61:546-53. 2. a. b. c. d. e. [385] Lamb, ME, Zhang C, Shea T, Kyle DJ, Leeb-Lundberg LM. 2002. Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells. Biochemistry. 41:14340-7.
Species	Human 1, 2 1. a. b. c. d. e. [420] Sabourin, T, Bastien L, Bachvarov DR, Marceau F. 2002. Agonist-induced translocation of the kinin B(1) receptor to caveolae-related rafts. Mol Pharmacol. 61:546-53. 2. a. b. c. d. e. f. [385] Lamb, ME, Zhang C, Shea T, Kyle DJ, Leeb-Lundberg LM. 2002. Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells. Biochemistry. 41:14340-7.
Receptor expression	Stable transfection 1, 2 1. a. b. c. d. e. f. [420] Sabourin, T, Bastien L, Bachvarov DR, Marceau F. 2002. Agonist-induced translocation of the kinin B(1) receptor to caveolae-related rafts. Mol Pharmacol. 61:546-53. 2. a. b. c. d. e. f. g. [385] Lamb, ME, Zhang C, Shea T, Kyle DJ, Leeb-Lundberg LM. 2002. Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells. Biochemistry. 41:14340-7.

Refrences

Human 1, 2

1. a. b. c. d. e. [420] Sabourin, T, Bastien L, Bachvarov DR, Marceau F. 2002. Agonist-induced translocation of the kinin B(1) receptor to caveolae-related rafts. Mol Pharmacol. 61:546-53.
2. a. b. c. d. e. f. [385] Lamb, ME, Zhang C, Shea T, Kyle DJ, Leeb-Lundberg LM. 2002. Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells. Biochemistry. 41:14340-7.