Adenosine A1 receptor

Organism	Rat1, Pig2, Syrian hamster3 1. [386] Lasley, RD, Narayan P, Uittenbogaard A, Smart EJ. 2000. Activated cardiac adenosine A(1) receptors translocate out of caveolae. J Biol Chem. 275:4417-21. 2. [363] Gines, S, Ciruela F, Burgueno J, Casado V, Canela EI, Mallol J, Lluis C, Franco R. 2001. Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol. 59:1314-23. 3. [357] Escriche, M, Burgueno J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluis C, Franco R. 2003. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Exp Cell Res. 285:72-90.
Functional implication	Agonist stimulation leads to translocation out of 1or into caveolae and caveolae-dependent internalization 2,3 1. a. b. [386] Lasley, RD, Narayan P, Uittenbogaard A, Smart EJ. 2000. Activated cardiac adenosine A(1) receptors translocate out of caveolae. J Biol Chem. 275:4417-21. 2. a. b. [363] Gines, S, Ciruela F, Burgueno J, Casado V, Canela EI, Mallol J, Lluis C, Franco R. 2001. Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol. 59:1314-23. 3. a. b. [357] Escriche, M, Burgueno J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluis C, Franco R. 2003. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Exp Cell Res. 285:72-90.
Methods used to detect raft association	Detergent-free1,2 Electron microscopy3, Confocal microscopy3 1. a. b. c. [386] Lasley, RD, Narayan P, Uittenbogaard A, Smart EJ. 2000. Activated cardiac adenosine A(1) receptors translocate out of caveolae. J Biol Chem. 275:4417-21. 2. a. b. c. [363] Gines, S, Ciruela F, Burgueno J, Casado V, Canela EI, Mallol J, Lluis C, Franco R. 2001. Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol. 59:1314-23. 3. a. b. c. d. [357] Escriche, M, Burgueno J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluis C, Franco R. 2003. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Exp Cell Res. 285:72-90.
Mechanism of raft association	Bound caveolin-31 and caveolin-13 1. a. b. c. d. [386] Lasley, RD, Narayan P, Uittenbogaard A, Smart EJ. 2000. Activated cardiac adenosine A(1) receptors translocate out of caveolae. J Biol Chem. 275:4417-21. 2. a. b. c. [363] Gines, S, Ciruela F, Burgueno J, Casado V, Canela EI, Mallol J, Lluis C, Franco R. 2001. Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol. 59:1314-23. 3. a. b. c. d. e. [357] Escriche, M, Burgueno J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluis C, Franco R. 2003. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Exp Cell Res. 285:72-90.
Caveolin-binding motif	Yes2 1. a. b. c. d. [386] Lasley, RD, Narayan P, Uittenbogaard A, Smart EJ. 2000. Activated cardiac adenosine A(1) receptors translocate out of caveolae. J Biol Chem. 275:4417-21. 2. a. b. c. d. [363] Gines, S, Ciruela F, Burgueno J, Casado V, Canela EI, Mallol J, Lluis C, Franco R. 2001. Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol. 59:1314-23. 3. a. b. c. d. e. [357] Escriche, M, Burgueno J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluis C, Franco R. 2003. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Exp Cell Res. 285:72-90.
Cell type	Ventricular cardiomyocyte1, Kidney epithelial cell2, Smooth muscle cell line3 1. a. b. c. d. e. [386] Lasley, RD, Narayan P, Uittenbogaard A, Smart EJ. 2000. Activated cardiac adenosine A(1) receptors translocate out of caveolae. J Biol Chem. 275:4417-21. 2. a. b. c. d. e. [363] Gines, S, Ciruela F, Burgueno J, Casado V, Canela EI, Mallol J, Lluis C, Franco R. 2001. Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol. 59:1314-23. 3. a. b. c. d. e. f. [357] Escriche, M, Burgueno J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluis C, Franco R. 2003. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Exp Cell Res. 285:72-90.
Species	Rat1, Pig2, Syrian hamster3 1. a. b. c. d. e. f. [386] Lasley, RD, Narayan P, Uittenbogaard A, Smart EJ. 2000. Activated cardiac adenosine A(1) receptors translocate out of caveolae. J Biol Chem. 275:4417-21. 2. a. b. c. d. e. f. [363] Gines, S, Ciruela F, Burgueno J, Casado V, Canela EI, Mallol J, Lluis C, Franco R. 2001. Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol. 59:1314-23. 3. a. b. c. d. e. f. g. [357] Escriche, M, Burgueno J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluis C, Franco R. 2003. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Exp Cell Res. 285:72-90.
Receptor expression	Endogenous1,2,3 1. a. b. c. d. e. f. g. [386] Lasley, RD, Narayan P, Uittenbogaard A, Smart EJ. 2000. Activated cardiac adenosine A(1) receptors translocate out of caveolae. J Biol Chem. 275:4417-21. 2. a. b. c. d. e. f. g. [363] Gines, S, Ciruela F, Burgueno J, Casado V, Canela EI, Mallol J, Lluis C, Franco R. 2001. Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol. 59:1314-23. 3. a. b. c. d. e. f. g. h. [357] Escriche, M, Burgueno J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluis C, Franco R. 2003. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Exp Cell Res. 285:72-90.

Refrences

Rat1, Pig2, Syrian hamster3

1. a. b. c. d. e. f. [386] Lasley, RD, Narayan P, Uittenbogaard A, Smart EJ. 2000. Activated cardiac adenosine A(1) receptors translocate out of caveolae. J Biol Chem. 275:4417-21.
2. a. b. c. d. e. f. [363] Gines, S, Ciruela F, Burgueno J, Casado V, Canela EI, Mallol J, Lluis C, Franco R. 2001. Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol. 59:1314-23.
3. a. b. c. d. e. f. g. [357] Escriche, M, Burgueno J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluis C, Franco R. 2003. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Exp Cell Res. 285:72-90.

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Adenosine A1 receptor