Adenosine A1 receptor

Organism	Rat 1, Pig 2, Syrian hamster 3 1. [386] Lasley, RD, Narayan P, Uittenbogaard A, Smart EJ. 2000. Activated cardiac adenosine A(1) receptors translocate out of caveolae. J Biol Chem. 275:4417-21. 2. [363] Gines, S, Ciruela F, Burgueno J, Casado V, Canela EI, Mallol J, Lluis C, Franco R. 2001. Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol. 59:1314-23. 3. [357] Escriche, M, Burgueno J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluis C, Franco R. 2003. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Exp Cell Res. 285:72-90.
Functional implication	Agonist stimulation leads to translocation out of 1or into caveolae and caveolae-dependent internalization 2,3 1. a. b. [386] Lasley, RD, Narayan P, Uittenbogaard A, Smart EJ. 2000. Activated cardiac adenosine A(1) receptors translocate out of caveolae. J Biol Chem. 275:4417-21. 2. a. b. [363] Gines, S, Ciruela F, Burgueno J, Casado V, Canela EI, Mallol J, Lluis C, Franco R. 2001. Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol. 59:1314-23. 3. a. b. [357] Escriche, M, Burgueno J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluis C, Franco R. 2003. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Exp Cell Res. 285:72-90.
Methods used to detect raft association	Detergent-free 1, 2 Electron microscopy 3; Confocal microscopy 3 1. a. b. c. [386] Lasley, RD, Narayan P, Uittenbogaard A, Smart EJ. 2000. Activated cardiac adenosine A(1) receptors translocate out of caveolae. J Biol Chem. 275:4417-21. 2. a. b. c. [363] Gines, S, Ciruela F, Burgueno J, Casado V, Canela EI, Mallol J, Lluis C, Franco R. 2001. Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol. 59:1314-23. 3. a. b. c. d. [357] Escriche, M, Burgueno J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluis C, Franco R. 2003. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Exp Cell Res. 285:72-90.
Mechanism of raft association	Bound caveolin-3 1 and caveolin-13 1. a. b. c. d. [386] Lasley, RD, Narayan P, Uittenbogaard A, Smart EJ. 2000. Activated cardiac adenosine A(1) receptors translocate out of caveolae. J Biol Chem. 275:4417-21. 2. a. b. c. [363] Gines, S, Ciruela F, Burgueno J, Casado V, Canela EI, Mallol J, Lluis C, Franco R. 2001. Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol. 59:1314-23. 3. a. b. c. d. e. [357] Escriche, M, Burgueno J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluis C, Franco R. 2003. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Exp Cell Res. 285:72-90.
Caveolin-binding motif	Yes 2 1. a. b. c. d. [386] Lasley, RD, Narayan P, Uittenbogaard A, Smart EJ. 2000. Activated cardiac adenosine A(1) receptors translocate out of caveolae. J Biol Chem. 275:4417-21. 2. a. b. c. d. [363] Gines, S, Ciruela F, Burgueno J, Casado V, Canela EI, Mallol J, Lluis C, Franco R. 2001. Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol. 59:1314-23. 3. a. b. c. d. e. [357] Escriche, M, Burgueno J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluis C, Franco R. 2003. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Exp Cell Res. 285:72-90.
Cell type	Ventricular cardiomyocyte 1; Kidney epithelial cell 2 Smooth muscle cell line 3 1. a. b. c. d. e. [386] Lasley, RD, Narayan P, Uittenbogaard A, Smart EJ. 2000. Activated cardiac adenosine A(1) receptors translocate out of caveolae. J Biol Chem. 275:4417-21. 2. a. b. c. d. e. [363] Gines, S, Ciruela F, Burgueno J, Casado V, Canela EI, Mallol J, Lluis C, Franco R. 2001. Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol. 59:1314-23. 3. a. b. c. d. e. f. [357] Escriche, M, Burgueno J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluis C, Franco R. 2003. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Exp Cell Res. 285:72-90.
Species	Rat 1; Pig 2; Syrian hamster 3 1. a. b. c. d. e. f. [386] Lasley, RD, Narayan P, Uittenbogaard A, Smart EJ. 2000. Activated cardiac adenosine A(1) receptors translocate out of caveolae. J Biol Chem. 275:4417-21. 2. a. b. c. d. e. f. [363] Gines, S, Ciruela F, Burgueno J, Casado V, Canela EI, Mallol J, Lluis C, Franco R. 2001. Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol. 59:1314-23. 3. a. b. c. d. e. f. g. [357] Escriche, M, Burgueno J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluis C, Franco R. 2003. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Exp Cell Res. 285:72-90.
Receptor expression	Endogenous 1, 2, 3 1. a. b. c. d. e. f. g. [386] Lasley, RD, Narayan P, Uittenbogaard A, Smart EJ. 2000. Activated cardiac adenosine A(1) receptors translocate out of caveolae. J Biol Chem. 275:4417-21. 2. a. b. c. d. e. f. g. [363] Gines, S, Ciruela F, Burgueno J, Casado V, Canela EI, Mallol J, Lluis C, Franco R. 2001. Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol. 59:1314-23. 3. a. b. c. d. e. f. g. h. [357] Escriche, M, Burgueno J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluis C, Franco R. 2003. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Exp Cell Res. 285:72-90.

Refrences

Rat 1; Pig 2; Syrian hamster 3

1. a. b. c. d. e. f. [386] Lasley, RD, Narayan P, Uittenbogaard A, Smart EJ. 2000. Activated cardiac adenosine A(1) receptors translocate out of caveolae. J Biol Chem. 275:4417-21.
2. a. b. c. d. e. f. [363] Gines, S, Ciruela F, Burgueno J, Casado V, Canela EI, Mallol J, Lluis C, Franco R. 2001. Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol. 59:1314-23.
3. a. b. c. d. e. f. g. [357] Escriche, M, Burgueno J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluis C, Franco R. 2003. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Exp Cell Res. 285:72-90.

Search whole site

Adenosine A1 receptor