Cannabinoid receptor

Organism	Human 1, 2 1. [421] Sarnataro, D, Grimaldi C, Pisanti S, Gazzerro P, Laezza C, Zurzolo C, Bifulco M. 2005. Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells. FEBS Lett. 579:6343-9. 2. [438] Wu, DF, Yang LQ, Goschke A, Stumm R, Brandenburg LO, Liang YJ, Hollt V, Koch T. 2008. Role of receptor internalization in the agonist-induced desensitization of cannabinoid type 1 receptors. J Neurochem. 104:1132-43.
Functional implication	Agonist treamtnet decreases the receptor associated with lipid raft 1; Receptor partially internalized via caveolae 3 1. a. b. [421] Sarnataro, D, Grimaldi C, Pisanti S, Gazzerro P, Laezza C, Zurzolo C, Bifulco M. 2005. Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells. FEBS Lett. 579:6343-9. 2. [438] Wu, DF, Yang LQ, Goschke A, Stumm R, Brandenburg LO, Liang YJ, Hollt V, Koch T. 2008. Role of receptor internalization in the agonist-induced desensitization of cannabinoid type 1 receptors. J Neurochem. 104:1132-43. 3. [378] Keren, O, Sarne Y. 2003. Multiple mechanisms of CB1 cannabinoid receptors regulation. Brain Res. 980:197-205.
Methods used to detect raft association	Detergent-free based on Opti prep density gradient 1; Confocal microscopy 1 1. a. b. c. d. [421] Sarnataro, D, Grimaldi C, Pisanti S, Gazzerro P, Laezza C, Zurzolo C, Bifulco M. 2005. Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells. FEBS Lett. 579:6343-9. 2. [438] Wu, DF, Yang LQ, Goschke A, Stumm R, Brandenburg LO, Liang YJ, Hollt V, Koch T. 2008. Role of receptor internalization in the agonist-induced desensitization of cannabinoid type 1 receptors. J Neurochem. 104:1132-43. 3. [378] Keren, O, Sarne Y. 2003. Multiple mechanisms of CB1 cannabinoid receptors regulation. Brain Res. 980:197-205.
Mechanism of raft association	n.a 1. a. b. c. d. [421] Sarnataro, D, Grimaldi C, Pisanti S, Gazzerro P, Laezza C, Zurzolo C, Bifulco M. 2005. Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells. FEBS Lett. 579:6343-9. 2. [438] Wu, DF, Yang LQ, Goschke A, Stumm R, Brandenburg LO, Liang YJ, Hollt V, Koch T. 2008. Role of receptor internalization in the agonist-induced desensitization of cannabinoid type 1 receptors. J Neurochem. 104:1132-43. 3. [378] Keren, O, Sarne Y. 2003. Multiple mechanisms of CB1 cannabinoid receptors regulation. Brain Res. 980:197-205.
Caveolin-binding motif
Cell type	Breast cancer MDA-MB-231 cells1; HEK-293 3,2 1. a. b. c. d. e. [421] Sarnataro, D, Grimaldi C, Pisanti S, Gazzerro P, Laezza C, Zurzolo C, Bifulco M. 2005. Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells. FEBS Lett. 579:6343-9. 2. a. b. [438] Wu, DF, Yang LQ, Goschke A, Stumm R, Brandenburg LO, Liang YJ, Hollt V, Koch T. 2008. Role of receptor internalization in the agonist-induced desensitization of cannabinoid type 1 receptors. J Neurochem. 104:1132-43. 3. a. b. [378] Keren, O, Sarne Y. 2003. Multiple mechanisms of CB1 cannabinoid receptors regulation. Brain Res. 980:197-205.
Species	Human 1, 3, 2 1. a. b. c. d. e. f. [421] Sarnataro, D, Grimaldi C, Pisanti S, Gazzerro P, Laezza C, Zurzolo C, Bifulco M. 2005. Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells. FEBS Lett. 579:6343-9. 2. a. b. c. [438] Wu, DF, Yang LQ, Goschke A, Stumm R, Brandenburg LO, Liang YJ, Hollt V, Koch T. 2008. Role of receptor internalization in the agonist-induced desensitization of cannabinoid type 1 receptors. J Neurochem. 104:1132-43. 3. a. b. c. [378] Keren, O, Sarne Y. 2003. Multiple mechanisms of CB1 cannabinoid receptors regulation. Brain Res. 980:197-205.
Receptor expression	Endogenous 1; Stable transfection 3, 2 1. a. b. c. d. e. f. g. [421] Sarnataro, D, Grimaldi C, Pisanti S, Gazzerro P, Laezza C, Zurzolo C, Bifulco M. 2005. Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells. FEBS Lett. 579:6343-9. 2. a. b. c. d. [438] Wu, DF, Yang LQ, Goschke A, Stumm R, Brandenburg LO, Liang YJ, Hollt V, Koch T. 2008. Role of receptor internalization in the agonist-induced desensitization of cannabinoid type 1 receptors. J Neurochem. 104:1132-43. 3. a. b. c. d. [378] Keren, O, Sarne Y. 2003. Multiple mechanisms of CB1 cannabinoid receptors regulation. Brain Res. 980:197-205.

Refrences

Human 1, 3, 2

1. a. b. c. d. e. f. [421] Sarnataro, D, Grimaldi C, Pisanti S, Gazzerro P, Laezza C, Zurzolo C, Bifulco M. 2005. Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells. FEBS Lett. 579:6343-9.
2. a. b. c. [438] Wu, DF, Yang LQ, Goschke A, Stumm R, Brandenburg LO, Liang YJ, Hollt V, Koch T. 2008. Role of receptor internalization in the agonist-induced desensitization of cannabinoid type 1 receptors. J Neurochem. 104:1132-43.
3. a. b. c. [378] Keren, O, Sarne Y. 2003. Multiple mechanisms of CB1 cannabinoid receptors regulation. Brain Res. 980:197-205.

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Cannabinoid receptor