Organism |
Rat , ; Human
|
Functional implication |
Agonist stimulation leads to translocation to caveolae or non-caveolin lipid raft or has no effect on localization ; Caveolin-binding mutation reduces the plasma membrane expression, agonist-dependent internalization and phospholipase C production ; Microtubules are essential in translocating the AT1 receptor to caveolae ; Receptors movement into caveolae is necessary for ROS production, Rac1 activation, Sos-1 tyrosine phosphorylation, ROS-dependent Akt phosphorylation and VSMC hypertrophy
|
Methods used to detect raft association |
Detergent-free,; Detergent-dependent ; Electron microscopy
|
Mechanism of raft association |
Bound caveolin-1
|
Caveolin-binding motif |
Yes
|
Cell type |
VSMC , , ; BHK and HEK cells ; COS-7 cells
|
Species |
Rat ; Hamster ; Human ; Monkey
|
Receptor expression |
Endogenous ; Transient transfection ,
|
Rat ; Hamster ; Human ; Monkey