Angiotensin II type 1 receptor

Organism

Rat 1, 2; Human 3

Functional implication

Agonist stimulation leads to translocation to caveolae 1 or non-caveolin lipid raft 2 or has no effect on localization 3; Caveolin-binding mutation reduces the plasma membrane expression, agonist-dependent internalization and phospholipase C production 3; Microtubules are essential in translocating the AT1 receptor to caveolae 4; Receptors movement into caveolae is necessary for ROS production, Rac1 activation, Sos-1 tyrosine phosphorylation, ROS-dependent Akt phosphorylation and VSMC hypertrophy 5

Methods used to detect raft association

Detergent-free1,2; Detergent-dependent 2; Electron microscopy 3

Mechanism of raft association

Bound caveolin-11

Caveolin-binding motif

Yes 2

Cell type

VSMC 1, 4, 5; BHK and HEK cells 2; COS-7 cells 3

Species

Rat 1; Hamster 2; Human 2; Monkey 3

Receptor expression

Endogenous 1; Transient transfection 2, 3

Refrences

Rat 1; Hamster 2; Human 2; Monkey 3