Angiotensin II type 1 receptor

Organism	Rat 1, 2; Human 3 1. [373] Ishizaka, N, Griendling KK, Lassegue B, Alexander RW. 1998. Angiotensin II type 1 receptor: relationship with caveolae and caveolin after initial agonist stimulation. Hypertension. 32:459-66. 2. [439] Wyse, BD, Prior IA, Qian H, Morrow IC, Nixon S, Muncke C, Kurzchalia TV, Thomas WG, Parton RG, Hancock JF. 2003. Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane. J Biol Chem. 278:23738-46. 3. [389] Leclerc, PC, Auger-Messier M, Lanctot PM, Escher E, Leduc R, Guillemette G. 2002. A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling. Endocrinology. 143:4702-10.
Functional implication	Agonist stimulation leads to translocation to caveolae 1 or non-caveolin lipid raft 2 or has no effect on localization 3; Caveolin-binding mutation reduces the plasma membrane expression, agonist-dependent internalization and phospholipase C production 3; Microtubules are essential in translocating the AT1 receptor to caveolae 4; Receptors movement into caveolae is necessary for ROS production, Rac1 activation, Sos-1 tyrosine phosphorylation, ROS-dependent Akt phosphorylation and VSMC hypertrophy 5 1. a. b. [373] Ishizaka, N, Griendling KK, Lassegue B, Alexander RW. 1998. Angiotensin II type 1 receptor: relationship with caveolae and caveolin after initial agonist stimulation. Hypertension. 32:459-66. 2. a. b. [439] Wyse, BD, Prior IA, Qian H, Morrow IC, Nixon S, Muncke C, Kurzchalia TV, Thomas WG, Parton RG, Hancock JF. 2003. Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane. J Biol Chem. 278:23738-46. 3. a. b. c. [389] Leclerc, PC, Auger-Messier M, Lanctot PM, Escher E, Leduc R, Guillemette G. 2002. A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling. Endocrinology. 143:4702-10. 4. [497] Zuo, L, Ushio-Fukai M, Hilenski LL, Alexander WR. 2004. Microtubules regulate angiotensin II type 1 receptor and Rac1 localization in caveolae/lipid rafts: role in redox signaling.. Arteriosclerosis, thrombosis, and vascular biology. 24(7):1223-8. 5. [498] Zuo, L, Ushio-Fukai M, Ikeda S, Hilenski L, Patrushev N, Alexander WR. 2005. Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells: role in redox signaling and vascular hypertrophy.. Arteriosclerosis, thrombosis, and vascular biology. 25(9):1824-30.
Methods used to detect raft association	Detergent-free1,2; Detergent-dependent 2; Electron microscopy 3 1. a. b. c. [373] Ishizaka, N, Griendling KK, Lassegue B, Alexander RW. 1998. Angiotensin II type 1 receptor: relationship with caveolae and caveolin after initial agonist stimulation. Hypertension. 32:459-66. 2. a. b. c. d. [439] Wyse, BD, Prior IA, Qian H, Morrow IC, Nixon S, Muncke C, Kurzchalia TV, Thomas WG, Parton RG, Hancock JF. 2003. Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane. J Biol Chem. 278:23738-46. 3. a. b. c. d. [389] Leclerc, PC, Auger-Messier M, Lanctot PM, Escher E, Leduc R, Guillemette G. 2002. A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling. Endocrinology. 143:4702-10. 4. [497] Zuo, L, Ushio-Fukai M, Hilenski LL, Alexander WR. 2004. Microtubules regulate angiotensin II type 1 receptor and Rac1 localization in caveolae/lipid rafts: role in redox signaling.. Arteriosclerosis, thrombosis, and vascular biology. 24(7):1223-8. 5. [498] Zuo, L, Ushio-Fukai M, Ikeda S, Hilenski L, Patrushev N, Alexander WR. 2005. Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells: role in redox signaling and vascular hypertrophy.. Arteriosclerosis, thrombosis, and vascular biology. 25(9):1824-30.
Mechanism of raft association	Bound caveolin-11 1. a. b. c. d. [373] Ishizaka, N, Griendling KK, Lassegue B, Alexander RW. 1998. Angiotensin II type 1 receptor: relationship with caveolae and caveolin after initial agonist stimulation. Hypertension. 32:459-66. 2. a. b. c. d. [439] Wyse, BD, Prior IA, Qian H, Morrow IC, Nixon S, Muncke C, Kurzchalia TV, Thomas WG, Parton RG, Hancock JF. 2003. Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane. J Biol Chem. 278:23738-46. 3. a. b. c. d. [389] Leclerc, PC, Auger-Messier M, Lanctot PM, Escher E, Leduc R, Guillemette G. 2002. A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling. Endocrinology. 143:4702-10. 4. [497] Zuo, L, Ushio-Fukai M, Hilenski LL, Alexander WR. 2004. Microtubules regulate angiotensin II type 1 receptor and Rac1 localization in caveolae/lipid rafts: role in redox signaling.. Arteriosclerosis, thrombosis, and vascular biology. 24(7):1223-8. 5. [498] Zuo, L, Ushio-Fukai M, Ikeda S, Hilenski L, Patrushev N, Alexander WR. 2005. Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells: role in redox signaling and vascular hypertrophy.. Arteriosclerosis, thrombosis, and vascular biology. 25(9):1824-30.
Caveolin-binding motif	Yes 2 1. a. b. c. d. [373] Ishizaka, N, Griendling KK, Lassegue B, Alexander RW. 1998. Angiotensin II type 1 receptor: relationship with caveolae and caveolin after initial agonist stimulation. Hypertension. 32:459-66. 2. a. b. c. d. e. [439] Wyse, BD, Prior IA, Qian H, Morrow IC, Nixon S, Muncke C, Kurzchalia TV, Thomas WG, Parton RG, Hancock JF. 2003. Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane. J Biol Chem. 278:23738-46. 3. a. b. c. d. [389] Leclerc, PC, Auger-Messier M, Lanctot PM, Escher E, Leduc R, Guillemette G. 2002. A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling. Endocrinology. 143:4702-10. 4. [497] Zuo, L, Ushio-Fukai M, Hilenski LL, Alexander WR. 2004. Microtubules regulate angiotensin II type 1 receptor and Rac1 localization in caveolae/lipid rafts: role in redox signaling.. Arteriosclerosis, thrombosis, and vascular biology. 24(7):1223-8. 5. [498] Zuo, L, Ushio-Fukai M, Ikeda S, Hilenski L, Patrushev N, Alexander WR. 2005. Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells: role in redox signaling and vascular hypertrophy.. Arteriosclerosis, thrombosis, and vascular biology. 25(9):1824-30.
Cell type	VSMC 1, 4, 5; BHK and HEK cells 2; COS-7 cells 3 1. a. b. c. d. e. [373] Ishizaka, N, Griendling KK, Lassegue B, Alexander RW. 1998. Angiotensin II type 1 receptor: relationship with caveolae and caveolin after initial agonist stimulation. Hypertension. 32:459-66. 2. a. b. c. d. e. f. [439] Wyse, BD, Prior IA, Qian H, Morrow IC, Nixon S, Muncke C, Kurzchalia TV, Thomas WG, Parton RG, Hancock JF. 2003. Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane. J Biol Chem. 278:23738-46. 3. a. b. c. d. e. [389] Leclerc, PC, Auger-Messier M, Lanctot PM, Escher E, Leduc R, Guillemette G. 2002. A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling. Endocrinology. 143:4702-10. 4. a. b. [497] Zuo, L, Ushio-Fukai M, Hilenski LL, Alexander WR. 2004. Microtubules regulate angiotensin II type 1 receptor and Rac1 localization in caveolae/lipid rafts: role in redox signaling.. Arteriosclerosis, thrombosis, and vascular biology. 24(7):1223-8. 5. a. b. [498] Zuo, L, Ushio-Fukai M, Ikeda S, Hilenski L, Patrushev N, Alexander WR. 2005. Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells: role in redox signaling and vascular hypertrophy.. Arteriosclerosis, thrombosis, and vascular biology. 25(9):1824-30.
Species	Rat 1; Hamster 2; Human 2; Monkey 3 1. a. b. c. d. e. f. [373] Ishizaka, N, Griendling KK, Lassegue B, Alexander RW. 1998. Angiotensin II type 1 receptor: relationship with caveolae and caveolin after initial agonist stimulation. Hypertension. 32:459-66. 2. a. b. c. d. e. f. g. h. [439] Wyse, BD, Prior IA, Qian H, Morrow IC, Nixon S, Muncke C, Kurzchalia TV, Thomas WG, Parton RG, Hancock JF. 2003. Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane. J Biol Chem. 278:23738-46. 3. a. b. c. d. e. f. [389] Leclerc, PC, Auger-Messier M, Lanctot PM, Escher E, Leduc R, Guillemette G. 2002. A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling. Endocrinology. 143:4702-10. 4. a. b. [497] Zuo, L, Ushio-Fukai M, Hilenski LL, Alexander WR. 2004. Microtubules regulate angiotensin II type 1 receptor and Rac1 localization in caveolae/lipid rafts: role in redox signaling.. Arteriosclerosis, thrombosis, and vascular biology. 24(7):1223-8. 5. a. b. [498] Zuo, L, Ushio-Fukai M, Ikeda S, Hilenski L, Patrushev N, Alexander WR. 2005. Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells: role in redox signaling and vascular hypertrophy.. Arteriosclerosis, thrombosis, and vascular biology. 25(9):1824-30.
Receptor expression	Endogenous 1; Transient transfection 2, 3 1. a. b. c. d. e. f. g. [373] Ishizaka, N, Griendling KK, Lassegue B, Alexander RW. 1998. Angiotensin II type 1 receptor: relationship with caveolae and caveolin after initial agonist stimulation. Hypertension. 32:459-66. 2. a. b. c. d. e. f. g. h. i. [439] Wyse, BD, Prior IA, Qian H, Morrow IC, Nixon S, Muncke C, Kurzchalia TV, Thomas WG, Parton RG, Hancock JF. 2003. Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane. J Biol Chem. 278:23738-46. 3. a. b. c. d. e. f. g. [389] Leclerc, PC, Auger-Messier M, Lanctot PM, Escher E, Leduc R, Guillemette G. 2002. A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling. Endocrinology. 143:4702-10. 4. a. b. [497] Zuo, L, Ushio-Fukai M, Hilenski LL, Alexander WR. 2004. Microtubules regulate angiotensin II type 1 receptor and Rac1 localization in caveolae/lipid rafts: role in redox signaling.. Arteriosclerosis, thrombosis, and vascular biology. 24(7):1223-8. 5. a. b. [498] Zuo, L, Ushio-Fukai M, Ikeda S, Hilenski L, Patrushev N, Alexander WR. 2005. Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells: role in redox signaling and vascular hypertrophy.. Arteriosclerosis, thrombosis, and vascular biology. 25(9):1824-30.

Refrences

Rat 1; Hamster 2; Human 2; Monkey 3

1. a. b. c. d. e. f. [373] Ishizaka, N, Griendling KK, Lassegue B, Alexander RW. 1998. Angiotensin II type 1 receptor: relationship with caveolae and caveolin after initial agonist stimulation. Hypertension. 32:459-66.
2. a. b. c. d. e. f. g. h. [439] Wyse, BD, Prior IA, Qian H, Morrow IC, Nixon S, Muncke C, Kurzchalia TV, Thomas WG, Parton RG, Hancock JF. 2003. Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane. J Biol Chem. 278:23738-46.
3. a. b. c. d. e. f. [389] Leclerc, PC, Auger-Messier M, Lanctot PM, Escher E, Leduc R, Guillemette G. 2002. A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling. Endocrinology. 143:4702-10.
4. a. b. [497] Zuo, L, Ushio-Fukai M, Hilenski LL, Alexander WR. 2004. Microtubules regulate angiotensin II type 1 receptor and Rac1 localization in caveolae/lipid rafts: role in redox signaling.. Arteriosclerosis, thrombosis, and vascular biology. 24(7):1223-8.
5. a. b. [498] Zuo, L, Ushio-Fukai M, Ikeda S, Hilenski L, Patrushev N, Alexander WR. 2005. Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells: role in redox signaling and vascular hypertrophy.. Arteriosclerosis, thrombosis, and vascular biology. 25(9):1824-30.

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Angiotensin II type 1 receptor