Microtubules regulate angiotensin II type 1 receptor and Rac1 localization in caveolae/lipid rafts: role in redox signaling.
| Title | Microtubules regulate angiotensin II type 1 receptor and Rac1 localization in caveolae/lipid rafts: role in redox signaling. |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | Zuo, L, Ushio-Fukai M, Hilenski LL, Alexander WR |
| Journal | Arteriosclerosis, thrombosis, and vascular biology |
| Volume | 24 |
| Issue | 7 |
| Pagination | 1223-8 |
| Date Published | 2004 Jul |
| ISSN | 1524-4636 |
| Keywords | Angiotensin II, Animals, Aorta, Caveolae, Epidermal Growth Factor, Hydrogen Peroxide, Hypertrophy, Membrane Microdomains, Microtubules, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Muscle, Smooth, Vascular, Myocytes, Smooth Muscle, Nocodazole, Oxidation-Reduction, Oxidative Stress, Phosphorylation, Protein Processing, Post-Translational, Protein Transport, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-akt, rac1 GTP-Binding Protein, Rats, Reactive Oxygen Species, Receptor, Angiotensin, Type 1, Receptor, Epidermal Growth Factor |
| Abstract | Microtubules are important in signal transduction temporal-spatial organization. Full expression of angiotensin II (Ang II) signaling in vascular smooth muscle cells (VSMCs) is dependent on the reactive oxygen species (ROS) derived from nicotinamide-adenine dinucleotide phosphate (NAD(P)H) oxidase and the dynamic association of the Ang II type 1 receptor (AT1R) with caveolae/lipid rafts. Translocation of the small GTPase Rac1 to the plasma membrane is an essential step for activation of NAD(P)H oxidase; however, its precise localization in the plasma membrane after agonist stimulation and how it is targeted are unknown. We hypothesized that microtubules are involved in regulating multiphasic Ang II signaling events in VSMC. |
| Alternate Journal | Arterioscler. Thromb. Vasc. Biol. |