Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells: role in redox signaling and vascular hypertrophy.
| Title | Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells: role in redox signaling and vascular hypertrophy. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Zuo, L, Ushio-Fukai M, Ikeda S, Hilenski L, Patrushev N, Alexander WR |
| Journal | Arteriosclerosis, thrombosis, and vascular biology |
| Volume | 25 |
| Issue | 9 |
| Pagination | 1824-30 |
| Date Published | 2005 Sep |
| ISSN | 1524-4636 |
| Keywords | Actin Cytoskeleton, Angiotensin II, Animals, Caveolin 1, Cells, Cultured, Hypertrophy, Membrane Microdomains, Muscle, Smooth, Vascular, NADPH Oxidase, Oxidation-Reduction, Phosphorylation, Proto-Oncogene Proteins c-akt, rac1 GTP-Binding Protein, Reactive Oxygen Species, Receptor, Angiotensin, Type 1, Receptor, Epidermal Growth Factor, RNA, Small Interfering, Signal Transduction, SOS1 Protein, Tyrosine, Vasoconstrictor Agents |
| Abstract | Angiotensin II (Ang II) is a potent mediator of vascular hypertrophy in vascular smooth muscle cells (VSMCs). These effects are mediated through the Ang II type 1 receptor (AT1R) and require its trafficking through caveolin-1 (Cav1)-enriched lipid rafts and reactive oxygen species (ROS) derived from Rac1-dependent NAD(P)H oxidase. The specific role(s) of Cav1 in AT1R signaling is incompletely understood. |
| Alternate Journal | Arterioscler. Thromb. Vasc. Biol. |