Calcium-sensing receptor

Organism	Bovine 1; Human 2 1. [379] Kifor, O, Diaz R, Butters R, Kifor I, Brown EM. 1998. The calcium-sensing receptor is localized in caveolin-rich plasma membrane domains of bovine parathyroid cells. J Biol Chem. 273:21708-13. 2. [376] Jung, SY, Kwak JO, Kim HW, Kim DS, Ryu SD, Ko CB, Cha SH. 2005. Calcium sensing receptor forms complex with and is up-regulated by caveolin-1 in cultured human osteosarcoma (Saos-2) cells. Exp Mol Med. 37:91-100.
Functional implication	Ischemic preconditioning increases ERK1/2 phosphorylation in caveolin-3-enriched fraction 3 1. [379] Kifor, O, Diaz R, Butters R, Kifor I, Brown EM. 1998. The calcium-sensing receptor is localized in caveolin-rich plasma membrane domains of bovine parathyroid cells. J Biol Chem. 273:21708-13. 2. [376] Jung, SY, Kwak JO, Kim HW, Kim DS, Ryu SD, Ko CB, Cha SH. 2005. Calcium sensing receptor forms complex with and is up-regulated by caveolin-1 in cultured human osteosarcoma (Saos-2) cells. Exp Mol Med. 37:91-100. 3. [431] Sun, J, Murphy E. Submitted. Calcium-sensing receptor: a sensor and mediator of ischemic preconditioning in the heart. Am J Physiol Heart Circ Physiol. 299:H1309-17.
Methods used to detect raft association	Detergent-free 1,3, 2; Detergent-dependent 2 1. a. b. [379] Kifor, O, Diaz R, Butters R, Kifor I, Brown EM. 1998. The calcium-sensing receptor is localized in caveolin-rich plasma membrane domains of bovine parathyroid cells. J Biol Chem. 273:21708-13. 2. a. b. c. [376] Jung, SY, Kwak JO, Kim HW, Kim DS, Ryu SD, Ko CB, Cha SH. 2005. Calcium sensing receptor forms complex with and is up-regulated by caveolin-1 in cultured human osteosarcoma (Saos-2) cells. Exp Mol Med. 37:91-100. 3. a. b. [431] Sun, J, Murphy E. Submitted. Calcium-sensing receptor: a sensor and mediator of ischemic preconditioning in the heart. Am J Physiol Heart Circ Physiol. 299:H1309-17.
Mechanism of raft association	Bound caveolin-11 AND caveolin-3 3 1. a. b. c. [379] Kifor, O, Diaz R, Butters R, Kifor I, Brown EM. 1998. The calcium-sensing receptor is localized in caveolin-rich plasma membrane domains of bovine parathyroid cells. J Biol Chem. 273:21708-13. 2. a. b. c. [376] Jung, SY, Kwak JO, Kim HW, Kim DS, Ryu SD, Ko CB, Cha SH. 2005. Calcium sensing receptor forms complex with and is up-regulated by caveolin-1 in cultured human osteosarcoma (Saos-2) cells. Exp Mol Med. 37:91-100. 3. a. b. c. [431] Sun, J, Murphy E. Submitted. Calcium-sensing receptor: a sensor and mediator of ischemic preconditioning in the heart. Am J Physiol Heart Circ Physiol. 299:H1309-17.
Caveolin-binding motif	Yes 2 1. a. b. c. [379] Kifor, O, Diaz R, Butters R, Kifor I, Brown EM. 1998. The calcium-sensing receptor is localized in caveolin-rich plasma membrane domains of bovine parathyroid cells. J Biol Chem. 273:21708-13. 2. a. b. c. d. [376] Jung, SY, Kwak JO, Kim HW, Kim DS, Ryu SD, Ko CB, Cha SH. 2005. Calcium sensing receptor forms complex with and is up-regulated by caveolin-1 in cultured human osteosarcoma (Saos-2) cells. Exp Mol Med. 37:91-100. 3. a. b. c. [431] Sun, J, Murphy E. Submitted. Calcium-sensing receptor: a sensor and mediator of ischemic preconditioning in the heart. Am J Physiol Heart Circ Physiol. 299:H1309-17.
Cell type	Parathyroid cells 1; Saos-2 cells 2; Cardiomyocytes 3 1. a. b. c. d. [379] Kifor, O, Diaz R, Butters R, Kifor I, Brown EM. 1998. The calcium-sensing receptor is localized in caveolin-rich plasma membrane domains of bovine parathyroid cells. J Biol Chem. 273:21708-13. 2. a. b. c. d. e. [376] Jung, SY, Kwak JO, Kim HW, Kim DS, Ryu SD, Ko CB, Cha SH. 2005. Calcium sensing receptor forms complex with and is up-regulated by caveolin-1 in cultured human osteosarcoma (Saos-2) cells. Exp Mol Med. 37:91-100. 3. a. b. c. d. [431] Sun, J, Murphy E. Submitted. Calcium-sensing receptor: a sensor and mediator of ischemic preconditioning in the heart. Am J Physiol Heart Circ Physiol. 299:H1309-17.
Species	Bovine 2; Human 2; Mouse 3 1. a. b. c. d. [379] Kifor, O, Diaz R, Butters R, Kifor I, Brown EM. 1998. The calcium-sensing receptor is localized in caveolin-rich plasma membrane domains of bovine parathyroid cells. J Biol Chem. 273:21708-13. 2. a. b. c. d. e. f. g. [376] Jung, SY, Kwak JO, Kim HW, Kim DS, Ryu SD, Ko CB, Cha SH. 2005. Calcium sensing receptor forms complex with and is up-regulated by caveolin-1 in cultured human osteosarcoma (Saos-2) cells. Exp Mol Med. 37:91-100. 3. a. b. c. d. e. [431] Sun, J, Murphy E. Submitted. Calcium-sensing receptor: a sensor and mediator of ischemic preconditioning in the heart. Am J Physiol Heart Circ Physiol. 299:H1309-17.
Receptor expression	Endogenous 1, 2 1. a. b. c. d. e. [379] Kifor, O, Diaz R, Butters R, Kifor I, Brown EM. 1998. The calcium-sensing receptor is localized in caveolin-rich plasma membrane domains of bovine parathyroid cells. J Biol Chem. 273:21708-13. 2. a. b. c. d. e. f. g. h. [376] Jung, SY, Kwak JO, Kim HW, Kim DS, Ryu SD, Ko CB, Cha SH. 2005. Calcium sensing receptor forms complex with and is up-regulated by caveolin-1 in cultured human osteosarcoma (Saos-2) cells. Exp Mol Med. 37:91-100. 3. a. b. c. d. e. [431] Sun, J, Murphy E. Submitted. Calcium-sensing receptor: a sensor and mediator of ischemic preconditioning in the heart. Am J Physiol Heart Circ Physiol. 299:H1309-17.

Refrences

Bovine 2; Human 2; Mouse 3

1. a. b. c. d. [379] Kifor, O, Diaz R, Butters R, Kifor I, Brown EM. 1998. The calcium-sensing receptor is localized in caveolin-rich plasma membrane domains of bovine parathyroid cells. J Biol Chem. 273:21708-13.
2. a. b. c. d. e. f. g. [376] Jung, SY, Kwak JO, Kim HW, Kim DS, Ryu SD, Ko CB, Cha SH. 2005. Calcium sensing receptor forms complex with and is up-regulated by caveolin-1 in cultured human osteosarcoma (Saos-2) cells. Exp Mol Med. 37:91-100.
3. a. b. c. d. e. [431] Sun, J, Murphy E. Submitted. Calcium-sensing receptor: a sensor and mediator of ischemic preconditioning in the heart. Am J Physiol Heart Circ Physiol. 299:H1309-17.

Search whole site

Calcium-sensing receptor