Thyrotropin receptor

Organism	Human 1, 2 1. [387] Latif, R, Ando T, Daniel S, Davies TF. 2003. Localization and regulation of thyrotropin receptors within lipid rafts. Endocrinology. 144:4725-8. 2. [388] Latif, R, Ando T, Davies TF. 2007. Lipid rafts are triage centers for multimeric and monomeric thyrotropin receptor regulation. Endocrinology. 148:3164-75.
Functional implication	Receptors move out of raft upon activation 1; MβCD treatment did not alter cAMP accumulation 2; Cav-1 knockdown increased cAMP accumulation 3 1. a. b. [387] Latif, R, Ando T, Daniel S, Davies TF. 2003. Localization and regulation of thyrotropin receptors within lipid rafts. Endocrinology. 144:4725-8. 2. a. b. [388] Latif, R, Ando T, Davies TF. 2007. Lipid rafts are triage centers for multimeric and monomeric thyrotropin receptor regulation. Endocrinology. 148:3164-75. 3. [338] Allen, JA, Yu JZ, Dave RH, Bhatnagar A, Roth BL, Rasenick MM. 2009. Caveolin-1 and lipid microdomains regulate Gs trafficking and attenuate Gs/adenylyl cyclase signaling. Mol Pharmacol. 76:1082-93.
Methods used to detect raft association	Confocal microscopy 1; Detergent-free 2 1. a. b. c. [387] Latif, R, Ando T, Daniel S, Davies TF. 2003. Localization and regulation of thyrotropin receptors within lipid rafts. Endocrinology. 144:4725-8. 2. a. b. c. [388] Latif, R, Ando T, Davies TF. 2007. Lipid rafts are triage centers for multimeric and monomeric thyrotropin receptor regulation. Endocrinology. 148:3164-75. 3. [338] Allen, JA, Yu JZ, Dave RH, Bhatnagar A, Roth BL, Rasenick MM. 2009. Caveolin-1 and lipid microdomains regulate Gs trafficking and attenuate Gs/adenylyl cyclase signaling. Mol Pharmacol. 76:1082-93.
Mechanism of raft association	n.a 1. a. b. c. [387] Latif, R, Ando T, Daniel S, Davies TF. 2003. Localization and regulation of thyrotropin receptors within lipid rafts. Endocrinology. 144:4725-8. 2. a. b. c. [388] Latif, R, Ando T, Davies TF. 2007. Lipid rafts are triage centers for multimeric and monomeric thyrotropin receptor regulation. Endocrinology. 148:3164-75. 3. [338] Allen, JA, Yu JZ, Dave RH, Bhatnagar A, Roth BL, Rasenick MM. 2009. Caveolin-1 and lipid microdomains regulate Gs trafficking and attenuate Gs/adenylyl cyclase signaling. Mol Pharmacol. 76:1082-93.
Caveolin-binding motif
Cell type	CHO cells 1,2; Thyrocytes 2 1. a. b. c. d. [387] Latif, R, Ando T, Daniel S, Davies TF. 2003. Localization and regulation of thyrotropin receptors within lipid rafts. Endocrinology. 144:4725-8. 2. a. b. c. d. e. [388] Latif, R, Ando T, Davies TF. 2007. Lipid rafts are triage centers for multimeric and monomeric thyrotropin receptor regulation. Endocrinology. 148:3164-75. 3. [338] Allen, JA, Yu JZ, Dave RH, Bhatnagar A, Roth BL, Rasenick MM. 2009. Caveolin-1 and lipid microdomains regulate Gs trafficking and attenuate Gs/adenylyl cyclase signaling. Mol Pharmacol. 76:1082-93.
Species	Hamster 1, 2; Rat 2 1. a. b. c. d. e. [387] Latif, R, Ando T, Daniel S, Davies TF. 2003. Localization and regulation of thyrotropin receptors within lipid rafts. Endocrinology. 144:4725-8. 2. a. b. c. d. e. f. g. [388] Latif, R, Ando T, Davies TF. 2007. Lipid rafts are triage centers for multimeric and monomeric thyrotropin receptor regulation. Endocrinology. 148:3164-75. 3. [338] Allen, JA, Yu JZ, Dave RH, Bhatnagar A, Roth BL, Rasenick MM. 2009. Caveolin-1 and lipid microdomains regulate Gs trafficking and attenuate Gs/adenylyl cyclase signaling. Mol Pharmacol. 76:1082-93.
Receptor expression	Stable transfection 1,2 1. a. b. c. d. e. f. [387] Latif, R, Ando T, Daniel S, Davies TF. 2003. Localization and regulation of thyrotropin receptors within lipid rafts. Endocrinology. 144:4725-8. 2. a. b. c. d. e. f. g. h. [388] Latif, R, Ando T, Davies TF. 2007. Lipid rafts are triage centers for multimeric and monomeric thyrotropin receptor regulation. Endocrinology. 148:3164-75. 3. [338] Allen, JA, Yu JZ, Dave RH, Bhatnagar A, Roth BL, Rasenick MM. 2009. Caveolin-1 and lipid microdomains regulate Gs trafficking and attenuate Gs/adenylyl cyclase signaling. Mol Pharmacol. 76:1082-93.

Refrences

Hamster 1, 2; Rat 2

1. a. b. c. d. e. [387] Latif, R, Ando T, Daniel S, Davies TF. 2003. Localization and regulation of thyrotropin receptors within lipid rafts. Endocrinology. 144:4725-8.
2. a. b. c. d. e. f. g. [388] Latif, R, Ando T, Davies TF. 2007. Lipid rafts are triage centers for multimeric and monomeric thyrotropin receptor regulation. Endocrinology. 148:3164-75.
3. [338] Allen, JA, Yu JZ, Dave RH, Bhatnagar A, Roth BL, Rasenick MM. 2009. Caveolin-1 and lipid microdomains regulate Gs trafficking and attenuate Gs/adenylyl cyclase signaling. Mol Pharmacol. 76:1082-93.

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Thyrotropin receptor