Skip to Main Content Area

Search whole site

Sphingosine 1-phosphate receptor

Organism	Human 1; Murine 2 1. [372] Igarashi, J, Michel T. 2000. Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction. J Biol Chem. 275:32363-70. 2. [380] Kohno, T, Wada A, Igarashi Y. 2002. N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization. FASEB J. 16:983-92.
Functional implication	Agonist induced translocation to the caveolae, Caveolin overexpression inhibited receptor function 1 1. a. b. [372] Igarashi, J, Michel T. 2000. Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction. J Biol Chem. 275:32363-70. 2. [380] Kohno, T, Wada A, Igarashi Y. 2002. N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization. FASEB J. 16:983-92.
Methods used to detect raft association	Detergent-free 1 1. a. b. c. [372] Igarashi, J, Michel T. 2000. Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction. J Biol Chem. 275:32363-70. 2. [380] Kohno, T, Wada A, Igarashi Y. 2002. N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization. FASEB J. 16:983-92.
Mechanism of raft association	Bound caveolin 1; N-glycan 2 1. a. b. c. d. [372] Igarashi, J, Michel T. 2000. Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction. J Biol Chem. 275:32363-70. 2. a. b. [380] Kohno, T, Wada A, Igarashi Y. 2002. N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization. FASEB J. 16:983-92.
Caveolin-binding motif
Cell type	COS-7 cells 1; CHO cells 2 1. a. b. c. d. e. [372] Igarashi, J, Michel T. 2000. Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction. J Biol Chem. 275:32363-70. 2. a. b. c. [380] Kohno, T, Wada A, Igarashi Y. 2002. N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization. FASEB J. 16:983-92.
Species	Monkey 1; Hamster 2 1. a. b. c. d. e. f. [372] Igarashi, J, Michel T. 2000. Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction. J Biol Chem. 275:32363-70. 2. a. b. c. d. [380] Kohno, T, Wada A, Igarashi Y. 2002. N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization. FASEB J. 16:983-92.
Receptor expression	Transient transfection 1; Stable transfection 2 1. a. b. c. d. e. f. g. [372] Igarashi, J, Michel T. 2000. Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction. J Biol Chem. 275:32363-70. 2. a. b. c. d. e. [380] Kohno, T, Wada A, Igarashi Y. 2002. N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization. FASEB J. 16:983-92.

Refrences

Monkey 1; Hamster 2

1. a. b. c. d. e. f. [372] Igarashi, J, Michel T. 2000. Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction. J Biol Chem. 275:32363-70.
2. a. b. c. d. [380] Kohno, T, Wada A, Igarashi Y. 2002. N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization. FASEB J. 16:983-92.