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Serotonin 5-HT1A receptor

Organism	Mouse 1 1. [413] Renner, U, Glebov K, Lang T, Papusheva E, Balakrishnan S, Keller B, Richter DW, Jahn R, Ponimaskin E. 2007. Localization of the mouse 5-hydroxytryptamine(1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signaling. Mol Pharmacol. 72:502-13.
Functional implication	Signaling reduces in cyclodextrin treated and palmitoylated-deficient cells 1 1. a. b. [413] Renner, U, Glebov K, Lang T, Papusheva E, Balakrishnan S, Keller B, Richter DW, Jahn R, Ponimaskin E. 2007. Localization of the mouse 5-hydroxytryptamine(1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signaling. Mol Pharmacol. 72:502-13.
Methods used to detect raft association	Gradient centrifugation 1, Copatching assay 1 1. a. b. c. d. [413] Renner, U, Glebov K, Lang T, Papusheva E, Balakrishnan S, Keller B, Richter DW, Jahn R, Ponimaskin E. 2007. Localization of the mouse 5-hydroxytryptamine(1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signaling. Mol Pharmacol. 72:502-13.
Mechanism of raft association	Palmitoylation 1 1. a. b. c. d. e. [413] Renner, U, Glebov K, Lang T, Papusheva E, Balakrishnan S, Keller B, Richter DW, Jahn R, Ponimaskin E. 2007. Localization of the mouse 5-hydroxytryptamine(1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signaling. Mol Pharmacol. 72:502-13.
Caveolin-binding motif
Cell type	NIH-3T3 cells 1; CHO cells 1 1. a. b. c. d. e. f. g. [413] Renner, U, Glebov K, Lang T, Papusheva E, Balakrishnan S, Keller B, Richter DW, Jahn R, Ponimaskin E. 2007. Localization of the mouse 5-hydroxytryptamine(1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signaling. Mol Pharmacol. 72:502-13.
Species	Mouse 1; Hamster 1 1. a. b. c. d. e. f. g. h. i. [413] Renner, U, Glebov K, Lang T, Papusheva E, Balakrishnan S, Keller B, Richter DW, Jahn R, Ponimaskin E. 2007. Localization of the mouse 5-hydroxytryptamine(1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signaling. Mol Pharmacol. 72:502-13.
Receptor expression	Stable transfection 1; Transient transfection 1 1. a. b. c. d. e. f. g. h. i. j. k. [413] Renner, U, Glebov K, Lang T, Papusheva E, Balakrishnan S, Keller B, Richter DW, Jahn R, Ponimaskin E. 2007. Localization of the mouse 5-hydroxytryptamine(1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signaling. Mol Pharmacol. 72:502-13.

Refrences

Mouse 1; Hamster 1

1. a. b. c. d. e. f. g. h. i. [413] Renner, U, Glebov K, Lang T, Papusheva E, Balakrishnan S, Keller B, Richter DW, Jahn R, Ponimaskin E. 2007. Localization of the mouse 5-hydroxytryptamine(1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signaling. Mol Pharmacol. 72:502-13.