Protease-activated receptor type 2 PAR-2

Receptor activation and barrier abrogation leads to receptor internalization 1;  MβCD  and filipin treatment in addition to caveolin-1 silencing reduced TF-VIIa-mediated cleavage of PAR-2 and IL-8 gene expression 2

• 1. a. b. [369] Hachem, JP, Houben E, Crumrine D, Man MQ, Schurer N, Roelandt T, Choi EH, Uchida Y, Brown BE, Feingold KR et al..  2006.  Serine protease signaling of epidermal permeability barrier homeostasis. J Invest Dermatol. 126:2074-86.
• 2. a. b. [340] Awasthi, V, Mandal SK, Papanna V, Rao LV, Pendurthi UR.  2007.  Modulation of tissue factor-factor VIIa signaling by lipid rafts and caveolae. Arterioscler Thromb Vasc Biol. 27:1447-55.

n.a

• 1. a. b. c. [369] Hachem, JP, Houben E, Crumrine D, Man MQ, Schurer N, Roelandt T, Choi EH, Uchida Y, Brown BE, Feingold KR et al..  2006.  Serine protease signaling of epidermal permeability barrier homeostasis. J Invest Dermatol. 126:2074-86.
• 2. a. b. c. d. [340] Awasthi, V, Mandal SK, Papanna V, Rao LV, Pendurthi UR.  2007.  Modulation of tissue factor-factor VIIa signaling by lipid rafts and caveolae. Arterioscler Thromb Vasc Biol. 27:1447-55.

Epidermis 1; Breast carcinoma cells line MDA-MB-231 2

• 1. a. b. c. d. [369] Hachem, JP, Houben E, Crumrine D, Man MQ, Schurer N, Roelandt T, Choi EH, Uchida Y, Brown BE, Feingold KR et al..  2006.  Serine protease signaling of epidermal permeability barrier homeostasis. J Invest Dermatol. 126:2074-86.
• 2. a. b. c. d. e. [340] Awasthi, V, Mandal SK, Papanna V, Rao LV, Pendurthi UR.  2007.  Modulation of tissue factor-factor VIIa signaling by lipid rafts and caveolae. Arterioscler Thromb Vasc Biol. 27:1447-55.

Endogenous 1, 2

• 1. a. b. c. d. e. f. [369] Hachem, JP, Houben E, Crumrine D, Man MQ, Schurer N, Roelandt T, Choi EH, Uchida Y, Brown BE, Feingold KR et al..  2006.  Serine protease signaling of epidermal permeability barrier homeostasis. J Invest Dermatol. 126:2074-86.
• 2. a. b. c. d. e. f. g. [340] Awasthi, V, Mandal SK, Papanna V, Rao LV, Pendurthi UR.  2007.  Modulation of tissue factor-factor VIIa signaling by lipid rafts and caveolae. Arterioscler Thromb Vasc Biol. 27:1447-55.