β1-adrenoreceptor

Organism	Rat 1 1. [418] Rybin, VO, Pak E, Alcott S, Steinberg SF. 2003. Developmental changes in beta2-adrenergic receptor signaling in ventricular myocytes: the role of Gi proteins and caveolae microdomains. Mol Pharmacol. 63:1338-48.
Functional implication	No functional implication observed upon agonist treatment or raft disruption 2, 3 1. [418] Rybin, VO, Pak E, Alcott S, Steinberg SF. 2003. Developmental changes in beta2-adrenergic receptor signaling in ventricular myocytes: the role of Gi proteins and caveolae microdomains. Mol Pharmacol. 63:1338-48. 2. [419] Rybin, VO, Xu X, Lisanti MP, Steinberg SF. 2000. Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway. J Biol Chem. 275:41447-57. 3. [440] Xiang, Y, Rybin VO, Steinberg SF, Kobilka B. 2002. Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes. J Biol Chem. 277:34280-6.
Methods used to detect raft association	Detergent-free 2, 4 1. [418] Rybin, VO, Pak E, Alcott S, Steinberg SF. 2003. Developmental changes in beta2-adrenergic receptor signaling in ventricular myocytes: the role of Gi proteins and caveolae microdomains. Mol Pharmacol. 63:1338-48. 2. a. b. [419] Rybin, VO, Xu X, Lisanti MP, Steinberg SF. 2000. Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway. J Biol Chem. 275:41447-57. 3. [440] Xiang, Y, Rybin VO, Steinberg SF, Kobilka B. 2002. Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes. J Biol Chem. 277:34280-6. 4. [424] Schwencke, C, Okumura S, Yamamoto M, Geng YJ, Ishikawa Y. 1999. Colocalization of beta-adrenergic receptors and caveolin within the plasma membrane. J Cell Biochem. 75:64-72.
Mechanism of raft association	Bound caveolin-1 4 1. [418] Rybin, VO, Pak E, Alcott S, Steinberg SF. 2003. Developmental changes in beta2-adrenergic receptor signaling in ventricular myocytes: the role of Gi proteins and caveolae microdomains. Mol Pharmacol. 63:1338-48. 2. a. b. [419] Rybin, VO, Xu X, Lisanti MP, Steinberg SF. 2000. Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway. J Biol Chem. 275:41447-57. 3. [440] Xiang, Y, Rybin VO, Steinberg SF, Kobilka B. 2002. Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes. J Biol Chem. 277:34280-6. 4. a. b. [424] Schwencke, C, Okumura S, Yamamoto M, Geng YJ, Ishikawa Y. 1999. Colocalization of beta-adrenergic receptors and caveolin within the plasma membrane. J Cell Biochem. 75:64-72.
Caveolin-binding motif	Yes 5 1. [418] Rybin, VO, Pak E, Alcott S, Steinberg SF. 2003. Developmental changes in beta2-adrenergic receptor signaling in ventricular myocytes: the role of Gi proteins and caveolae microdomains. Mol Pharmacol. 63:1338-48. 2. a. b. [419] Rybin, VO, Xu X, Lisanti MP, Steinberg SF. 2000. Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway. J Biol Chem. 275:41447-57. 3. [440] Xiang, Y, Rybin VO, Steinberg SF, Kobilka B. 2002. Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes. J Biol Chem. 277:34280-6. 4. a. b. [424] Schwencke, C, Okumura S, Yamamoto M, Geng YJ, Ishikawa Y. 1999. Colocalization of beta-adrenergic receptors and caveolin within the plasma membrane. J Cell Biochem. 75:64-72. 5. [405] Ostrom, RS, Post SR, Insel PA. 2000. Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving G(s). J Pharmacol Exp Ther. 294:407-12.
Cell type	COS-7 cells 4, Cardiomyocytes 1, Cardiac fibroblastas 2; Neonatal myocytes 3 1. a. b. [418] Rybin, VO, Pak E, Alcott S, Steinberg SF. 2003. Developmental changes in beta2-adrenergic receptor signaling in ventricular myocytes: the role of Gi proteins and caveolae microdomains. Mol Pharmacol. 63:1338-48. 2. a. b. c. [419] Rybin, VO, Xu X, Lisanti MP, Steinberg SF. 2000. Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway. J Biol Chem. 275:41447-57. 3. a. b. [440] Xiang, Y, Rybin VO, Steinberg SF, Kobilka B. 2002. Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes. J Biol Chem. 277:34280-6. 4. a. b. c. [424] Schwencke, C, Okumura S, Yamamoto M, Geng YJ, Ishikawa Y. 1999. Colocalization of beta-adrenergic receptors and caveolin within the plasma membrane. J Cell Biochem. 75:64-72. 5. [405] Ostrom, RS, Post SR, Insel PA. 2000. Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving G(s). J Pharmacol Exp Ther. 294:407-12.
Species	Monkey 4; Rat 1, 2, Mouse 3 1. a. b. c. [418] Rybin, VO, Pak E, Alcott S, Steinberg SF. 2003. Developmental changes in beta2-adrenergic receptor signaling in ventricular myocytes: the role of Gi proteins and caveolae microdomains. Mol Pharmacol. 63:1338-48. 2. a. b. c. d. [419] Rybin, VO, Xu X, Lisanti MP, Steinberg SF. 2000. Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway. J Biol Chem. 275:41447-57. 3. a. b. c. [440] Xiang, Y, Rybin VO, Steinberg SF, Kobilka B. 2002. Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes. J Biol Chem. 277:34280-6. 4. a. b. c. d. [424] Schwencke, C, Okumura S, Yamamoto M, Geng YJ, Ishikawa Y. 1999. Colocalization of beta-adrenergic receptors and caveolin within the plasma membrane. J Cell Biochem. 75:64-72. 5. [405] Ostrom, RS, Post SR, Insel PA. 2000. Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving G(s). J Pharmacol Exp Ther. 294:407-12.
Receptor expression	Endogenous 1, 3; Transient transfection 4 1. a. b. c. d. [418] Rybin, VO, Pak E, Alcott S, Steinberg SF. 2003. Developmental changes in beta2-adrenergic receptor signaling in ventricular myocytes: the role of Gi proteins and caveolae microdomains. Mol Pharmacol. 63:1338-48. 2. a. b. c. d. [419] Rybin, VO, Xu X, Lisanti MP, Steinberg SF. 2000. Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway. J Biol Chem. 275:41447-57. 3. a. b. c. d. [440] Xiang, Y, Rybin VO, Steinberg SF, Kobilka B. 2002. Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes. J Biol Chem. 277:34280-6. 4. a. b. c. d. e. [424] Schwencke, C, Okumura S, Yamamoto M, Geng YJ, Ishikawa Y. 1999. Colocalization of beta-adrenergic receptors and caveolin within the plasma membrane. J Cell Biochem. 75:64-72. 5. [405] Ostrom, RS, Post SR, Insel PA. 2000. Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving G(s). J Pharmacol Exp Ther. 294:407-12.

Refrences

Monkey 4; Rat 1, 2, Mouse 3

1. a. b. c. [418] Rybin, VO, Pak E, Alcott S, Steinberg SF. 2003. Developmental changes in beta2-adrenergic receptor signaling in ventricular myocytes: the role of Gi proteins and caveolae microdomains. Mol Pharmacol. 63:1338-48.
2. a. b. c. d. [419] Rybin, VO, Xu X, Lisanti MP, Steinberg SF. 2000. Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway. J Biol Chem. 275:41447-57.
3. a. b. c. [440] Xiang, Y, Rybin VO, Steinberg SF, Kobilka B. 2002. Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes. J Biol Chem. 277:34280-6.
4. a. b. c. d. [424] Schwencke, C, Okumura S, Yamamoto M, Geng YJ, Ishikawa Y. 1999. Colocalization of beta-adrenergic receptors and caveolin within the plasma membrane. J Cell Biochem. 75:64-72.
5. [405] Ostrom, RS, Post SR, Insel PA. 2000. Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving G(s). J Pharmacol Exp Ther. 294:407-12.

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β1-adrenoreceptor